Biology:KCNB2

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Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Potassium voltage-gated channel subfamily B member 2 is a protein that in humans is encoded by the KCNB2 gene.^[1]^[2] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[1]^[2]

References

↑ ^1.0 ^1.1 "Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles". The American Journal of Physiology 274 (5): G901–G911. May 1998. doi:10.1152/ajpgi.1998.274.5.G901. PMID 9612272.
↑ ^2.0 ^2.1 "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews 57 (4): 473–508. December 2005. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

"A high-density association screen of 155 ion transport genes for involvement with common migraine". Human Molecular Genetics 17 (21): 3318–3331. November 2008. doi:10.1093/hmg/ddn227. PMID 18676988.
"Expression of voltage-gated potassium channels in human and rhesus pancreatic islets". Diabetes 53 (3): 597–607. March 2004. doi:10.2337/diabetes.53.3.597. PMID 14988243.
"Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". The EMBO Journal 15 (13): 3322–3331. July 1996. doi:10.1002/j.1460-2075.1996.tb00697.x. PMID 8670833.
"Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis". Human Molecular Genetics 18 (4): 767–778. February 2009. doi:10.1093/hmg/ddn388. PMID 19010793.
"Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study". BMC Medical Genetics 8 (Suppl 1): S2. September 2007. doi:10.1186/1471-2350-8-S1-S2. PMID 17903301.
"Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics 7 (11): 1775–1785. June 2007. doi:10.1002/pmic.200601006. PMID 17474147.
"Modes of regulation of shab K+ channel activity by the Kv8.1 subunit". The Journal of Biological Chemistry 272 (13): 8774–8780. March 1997. doi:10.1074/jbc.272.13.8774. PMID 9079713.

External links

Kv2.2+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
KCNB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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