Biology:TRPM7

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.

Function

TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.

Interactions

TRPM7 has been shown to interact with PLCB1 and PLCB2.

Clinical relevance

Defects in this gene have been associated with magnesium deficiency in human microvascular endothelial cells.

See also

• TRPM

Further reading

• "Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis". Pflügers Arch. 451 (1): 228–34. 2005. doi:10.1007/s00424-005-1470-y. PMID 16075242. 
• "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. 2005. doi:10.1124/pr.57.4.6. PMID 16382100. 
• "The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. 179. 2007. pp. 313–28. doi:10.1007/978-3-540-34891-7_19. ISBN 978-3-540-34889-4. 

External links

• TRPM7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.