Biology:KCNK18
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K2P18.1 is a potassium channel containing two pore-forming P domains.[1]
A flaw in this gene could help trigger migraine headaches. If the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.[2]
See also
- Tandem pore domain potassium channel
References
- ↑ "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. December 2005. doi:10.1124/pr.57.4.12. PMID 16382106. https://escholarship.org/uc/item/3k15p5vt.
- ↑ "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura". Nature Medicine 16 (10): 1157–1160. September 2010. doi:10.1038/nm.2216. PMID 20871611.
- "Migraine cause 'identified' as genetic defect". BBC News. 2010-09-27. https://www.bbc.co.uk/news/health-11408113.
Further reading
- "Functional analysis of missense variants in the TRESK (KCNK18) K+ channel.". Scientific Reports 2: article number 237. 2012. doi:10.1038/srep00237. PMID 22355750.
- "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin". J. Biol. Chem. 279 (18): 18550–8. 2004. doi:10.1074/jbc.M312229200. PMID 14981085.
- "Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family". J. Biol. Chem. 279 (27): 28063–70. 2004. doi:10.1074/jbc.M402940200. PMID 15123670.
- "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
- "Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation". J. Biol. Chem. 283 (23): 15672–80. 2008. doi:10.1074/jbc.M800712200. PMID 18397886.
- "TRESK-like potassium channels in leukemic T cells". Pflügers Arch. 456 (6): 1037–48. 2008. doi:10.1007/s00424-008-0481-x. PMID 18506476.
- "A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord". J. Biol. Chem. 278 (30): 27406–12. 2003. doi:10.1074/jbc.M206810200. PMID 12754259.
External links
- KCNK18+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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