Biology:CLNS1A

Short description: Protein-coding gene in humans

Generic protein structure example

Methylosome subunit pICln is a protein that in humans is encoded by the CLNS1A gene.

Interactions

CLNS1A has been shown to interact with:

• ITGA2B,
• PRMT5,
• SNRPD1, and
• SNRPD3.

See also

• Chloride channel

Further reading

• "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium". Front. Biosci. 11: 1646–66. 2006. doi:10.2741/1911. PMID 16368544. https://digital.library.unt.edu/ark:/67531/metadc892527/. 
• "The ubiquitously expressed pICln protein forms homomeric complexes in vitro". Biochem. Biophys. Res. Commun. 218 (3): 822–7. 1996. doi:10.1006/bbrc.1996.0146. PMID 8579598. 
• "Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: association with actin". Biochem. J. 327 (2): 609–16. 1997. doi:10.1042/bj3270609. PMID 9359436. 
• "Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma". Cytogenet. Cell Genet. 79 (1–2): 125–31. 1998. doi:10.1159/000134699. PMID 9533029. 
• "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology". J. Biol. Chem. 273 (18): 10811–4. 1998. doi:10.1074/jbc.273.18.10811. PMID 9556550. 
• "The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation". Blood 92 (4): 1442–7. 1998. doi:10.1182/blood.V92.4.1442. PMID 9694734. 
• "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins". Mol. Cell. Biol. 19 (6): 4113–20. 1999. doi:10.1128/MCB.19.6.4113. PMID 10330151. 
• "Modulation of volume regulated anion current by I(Cln)". Biochim. Biophys. Acta 1466 (1–2): 105–14. 2000. doi:10.1016/S0005-2736(00)00177-2. PMID 10825435. 
• "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. 21 (24): 8289–300. 2001. doi:10.1128/MCB.21.24.8289-8300.2001. PMID 11713266. 
• "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln". Curr. Biol. 11 (24): 1990–4. 2002. doi:10.1016/S0960-9822(01)00592-9. PMID 11747828. 
• "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. 2002. doi:10.1074/jbc.M109984200. PMID 11756452. 
• "Volume-regulated Cl⁻ channels in human pleural mesothelioma cells". FEBS Lett. 559 (1–3): 45–50. 2004. doi:10.1016/S0014-5793(04)00020-1. PMID 14960305. 
• "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. 279 (26): 27286–93. 2004. doi:10.1074/jbc.M402159200. PMID 15075326. 
• "ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4". J. Biol. Chem. 280 (35): 31276–82. 2005. doi:10.1074/jbc.M500541200. PMID 15905169. 
• "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes". J. Biol. Chem. 280 (41): 34435–40. 2005. doi:10.1074/jbc.M505077200. PMID 16087681. 

External links

• CLNS1A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CLNS1A genome location and CLNS1A gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.