Biology:KCNMB1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Calcium-activated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNMB1 gene.

Function

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Beta subunits (beta 1-4) are highly tissue specific in their expression, with beta-1 being present predominantly on vascular smooth muscle. Endothelial cells are not known to express beta-1 subunits. Beta-1 is also known to be expressed in urinary bladder and in some regions of the brain. Association of the beta-1 subunit with the BK channel increases the apparent Ca²⁺ sensitivity of the channel and decreases voltage dependence.

See also

• BK channel
• Voltage-gated potassium channel

Further reading

• "New disguises for an old channel: MaxiK channel beta-subunits". News in Physiological Sciences 17 (4): 156–61. Aug 2002. doi:10.1152/nips.01387.2002. PMID 12136044. 
• "Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle". The Journal of Biological Chemistry 269 (25): 17274–8. Jun 1994. doi:10.1016/S0021-9258(17)32551-6. PMID 8006036. 
• "A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels". FEBS Letters 382 (1–2): 84–8. Mar 1996. doi:10.1016/0014-5793(96)00151-2. PMID 8612769. 
• "Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation". The Journal of Neuroscience 16 (15): 4543–50. Aug 1996. doi:10.1523/JNEUROSCI.16-15-04543.1996. PMID 8764643. 
• "Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit". Science 285 (5435): 1929–31. Sep 1999. doi:10.1126/science.285.5435.1929. PMID 10489376. 
• "A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin". Proceedings of the National Academy of Sciences of the United States of America 97 (10): 5562–7. May 2000. doi:10.1073/pnas.100118597. PMID 10792058. Bibcode: 2000PNAS...97.5562M. 
• "Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit". The Journal of Biological Chemistry 277 (12): 10014–20. Mar 2002. doi:10.1074/jbc.M107682200. PMID 11790768. 
• "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1". The Journal of Biological Chemistry 277 (25): 22119–22. Jun 2002. doi:10.1074/jbc.C200215200. PMID 11994272. 
• "The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation". Journal of Hypertension 20 (5): 927–33. May 2002. doi:10.1097/00004872-200205000-00028. PMID 12011654. 
• "Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels". The Journal of Biological Chemistry 277 (46): 43724–9. Nov 2002. doi:10.1074/jbc.M205795200. PMID 12223479. 
• "Calcium-activated potassium channel expression in human myometrium: effect of pregnancy". Proceedings of the Western Pharmacology Society 45: 184–6. 2003. PMID 12434576. 
• "Role of hbeta1 in activation of human mesangial BK channels by cGMP kinase". American Journal of Physiology. Renal Physiology 285 (2): F289-94. Aug 2003. doi:10.1152/ajprenal.00046.2003. PMID 12670831. 
• "Beta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms". Proceedings of the National Academy of Sciences of the United States of America 100 (17): 10061–6. Aug 2003. doi:10.1073/pnas.1731650100. PMID 12893878. Bibcode: 2003PNAS..10010061Q. 
• "Current transients associated with BK channels in human glioma cells". The Journal of Membrane Biology 193 (3): 201–13. Jun 2003. doi:10.1007/s00232-003-2019-7. PMID 12962281. 
• "Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia". The Journal of Biological Chemistry 278 (51): 51422–32. Dec 2003. doi:10.1074/jbc.M309463200. PMID 14522958. 
• "Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension". The Journal of Clinical Investigation 113 (7): 1032–9. Apr 2004. doi:10.1172/JCI20347. PMID 15057310. PMC 379324. http://repositori.upf.edu/bitstream/10230/25630/1/Fernandez_cli_gai.pdf. 
• "Dynamic regulation of β1 subunit trafficking controls vascular contractility". Proceedings of the National Academy of Sciences of the United States of America 111 (6): 2361–6. Feb 2014. doi:10.1073/pnas.1317527111. PMID 24464482. Bibcode: 2014PNAS..111.2361L. 
• "Both transmembrane domains of BK β1 subunits are essential to confer the normal phenotype of β1-containing BK channels". PLOS ONE 9 (10): e109306. 2014. doi:10.1371/journal.pone.0109306. PMID 25275635. Bibcode: 2014PLoSO...9j9306K. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.