Biology:KCNJ3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

G protein-activated inward rectifier potassium channel 1 (GIRK-1) is encoded in the human by the gene KCNJ3.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex.

Interactions

KCNJ3 has been shown to interact with KCNJ5.

See also

• G protein-coupled inwardly-rectifying potassium channel
• Inward-rectifier potassium ion channel

Further reading

• "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. 2006. doi:10.1124/pr.57.4.11. PMID 16382105. 
• "Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism". Genomics 21 (1): 254–6. 1994. doi:10.1006/geno.1994.1253. PMID 8088798. 
• "Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum". Brain Res. Mol. Brain Res. 39 (1–2): 23–30. 1996. doi:10.1016/0169-328X(95)00349-W. PMID 8804710. 
• "A recombinant inwardly rectifying potassium channel coupled to GTP- binding proteins". J. Gen. Physiol. 107 (3): 381–97. 1996. doi:10.1085/jgp.107.3.381. PMID 8868049. 
• "Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain". J. Neurosci. 16 (22): 7137–50. 1996. doi:10.1523/JNEUROSCI.16-22-07137.1996. PMID 8929423. 
• "Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2". Proc. Natl. Acad. Sci. U.S.A. 94 (3): 923–7. 1997. doi:10.1073/pnas.94.3.923. PMID 9023358. Bibcode: 1997PNAS...94..923S. 
• "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Lett. 405 (3): 291–8. 1997. doi:10.1016/S0014-5793(97)00197-X. PMID 9108307. 
• "Genomic organization and promoter analysis of the human G-protein-coupled K+ channel Kir3.1 (KCNJ3/HGIRK1)". Genomics 39 (3): 279–88. 1997. doi:10.1006/geno.1996.4495. PMID 9119365. 
• "Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers". J. Biol. Chem. 273 (42): 27499–504. 1998. doi:10.1074/jbc.273.42.27499. PMID 9765280. 
• "GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels". J. Biol. Chem. 274 (4): 2571–82. 1999. doi:10.1074/jbc.274.4.2571. PMID 9891030. 
• "Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function". J. Biol. Chem. 275 (39): 30677–82. 2000. doi:10.1074/jbc.M005338200. PMID 10889209. 
• "Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins". J. Biol. Chem. 277 (8): 6088–96. 2002. doi:10.1074/jbc.M104851200. PMID 11741896. 
• "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: Implication for Andersen's syndrome". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8430–5. 2002. doi:10.1073/pnas.122682899. PMID 12034888. Bibcode: 2002PNAS...99.8430C. 
• "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. Chem. 277 (48): 46010–9. 2003. doi:10.1074/jbc.M205035200. PMID 12297500. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel". J. Biol. Chem. 278 (31): 29174–83. 2003. doi:10.1074/jbc.M304518200. PMID 12743112. 
• "Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses". Blood 104 (5): 1335–43. 2004. doi:10.1182/blood-2004-01-0069. PMID 15142872. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines". BMC Cancer 5: 104. 2006. doi:10.1186/1471-2407-5-104. PMID 16109170. 

External links

• KCNJ3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.