Biology:TRPC1
 Generic protein structure example |
Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the TRPC1 gene.[1][2]
Function
TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types. [3] It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the phospholipase C system. In HEK293 cells the unitary current-voltage relationship of endogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV.[4] The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5. [5][6] The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.[6]
History
TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the TRP channel in Drosophila. Together with TRPC3 they became the founding members of the TRPC ion channel family.[1][2]
Interactions
TRPC1 has been shown to interact with:
See also
References
- ↑ 1.0 1.1 "TRPC1, a human homolog of a Drosophila store-operated channel". Proceedings of the National Academy of Sciences of the United States of America 92 (21): 9652–6. Oct 1995. doi:10.1073/pnas.92.21.9652. PMID 7568191. Bibcode: 1995PNAS...92.9652W.
- ↑ 2.0 2.1 "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene". FEBS Letters 373 (3): 193–8. Oct 1995. doi:10.1016/0014-5793(95)01038-G. PMID 7589464.
- ↑ "TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells". Circulation Research 88 (1): 84–7. Jan 2001. doi:10.1161/01.res.88.1.84. PMID 11139478.
- ↑ "TRPC1 protein forms only one type of native store-operated channels in HEK293 cells". Biochimie 95 (2): 347–53. Feb 2013. doi:10.1016/j.biochi.2012.10.004. PMID 23079337.
- ↑ "Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain". PLOS ONE 2 (6): e573. 2007. doi:10.1371/journal.pone.0000573. PMID 17593972. Bibcode: 2007PLoSO...2..573F.
- ↑ 6.0 6.1 Cooper, Donald; Fowler, Melissa; Varnell, Andrew; Dietrich, A.; Birnbaumer, L.; Cooper, Donald (2012). "Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine". Nature Precedings. doi:10.1038/npre.2012.7153.
- ↑ "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell 114 (6): 777–89. Sep 2003. doi:10.1016/s0092-8674(03)00716-5. PMID 14505576.
- ↑ "Specific association of the gene product of PKD2 with the TRPC1 channel". Proceedings of the National Academy of Sciences of the United States of America 96 (7): 3934–9. Mar 1999. doi:10.1073/pnas.96.7.3934. PMID 10097141. Bibcode: 1999PNAS...96.3934T.
- ↑ "RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability". The Journal of Biological Chemistry 278 (35): 33492–500. Aug 2003. doi:10.1074/jbc.M302401200. PMID 12766172.
- ↑ 10.0 10.1 10.2 "Formation of novel TRPC channels by complex subunit interactions in embryonic brain". The Journal of Biological Chemistry 278 (40): 39014–9. Oct 2003. doi:10.1074/jbc.M306705200. PMID 12857742.
- ↑ "Coassembly of TRP and TRPL produces a distinct store-operated conductance". Cell 89 (7): 1155–64. Jun 1997. doi:10.1016/s0092-8674(00)80302-5. PMID 9215637.
- ↑ 12.0 12.1 "Subunit composition of mammalian transient receptor potential channels in living cells". Proceedings of the National Academy of Sciences of the United States of America 99 (11): 7461–6. May 2002. doi:10.1073/pnas.102596199. PMID 12032305. Bibcode: 2002PNAS...99.7461H.
Further reading
- "TRPC1 Ca2+-Permeable Channels in Animal Cells". TRPC1 Ca(2+)-permeable channels in animal cells. Handbook of Experimental Pharmacology. 179. 2007. pp. 23–52. doi:10.1007/978-3-540-34891-7_2. ISBN 978-3-540-34889-4.
- "TRPC1: a core component of store-operated calcium channels". Biochemical Society Transactions 35 (Pt 1): 96–100. Feb 2007. doi:10.1042/BST0350096. PMID 17233611.
External links
- TRPC1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- "TRIP Database". a manually curated database of protein-protein interactions for mammalian TRP channels. http://www.trpchannel.org.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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