Biology:KCNJ16

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the K_ir5.1 protein.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir5.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir5.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may be involved in the regulation of fluid and pH balance. Three transcript variants encoding the same protein have been found for this gene.

See also

• Inward-rectifier potassium ion channel

Further reading

• "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. 2006. doi:10.1124/pr.57.4.11. PMID 16382105. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver". J. Physiol. 514 ( Pt 3) (3): 639–53. 1999. doi:10.1111/j.1469-7793.1999.639ad.x. PMID 9882736. 
• "The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas". Cytogenet. Cell Genet. 90 (1–2): 60–3. 2000. doi:10.1159/000015662. PMID 11060447. 
• "Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits". FEBS Lett. 491 (3): 305–11. 2001. doi:10.1016/S0014-5793(01)02202-5. PMID 11240146. 
• "Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1". J. Physiol. 532 (Pt 2): 359–67. 2001. doi:10.1111/j.1469-7793.2001.0359f.x. PMID 11306656. 
• "PSD-95 mediates formation of a functional homomeric Kir5.1 channel in the brain". Neuron 34 (3): 387–97. 2002. doi:10.1016/S0896-6273(02)00675-X. PMID 11988170. 
• "Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels". Am. J. Physiol., Cell Physiol. 284 (4): C910–7. 2003. doi:10.1152/ajpcell.00479.2002. PMID 12456399. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels". J. Biol. Chem. 278 (44): 43533–40. 2003. doi:10.1074/jbc.M306596200. PMID 12923169. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.