Biology:CLCN6
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene.[1][2]
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.[2]
See also
References
- ↑ "ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family". FEBS Lett 377 (1): 15–20. Feb 1996. doi:10.1016/0014-5793(95)01298-2. PMID 8543009.
- ↑ 2.0 2.1 "Entrez Gene: CLCN6 chloride channel 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1185.
Further reading
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. 2003. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. 1995. doi:10.1093/dnares/1.5.223. PMID 7584044.
- "Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific". Biochem. J. 325 (Pt 1): 269–76. 1997. doi:10.1042/bj3250269. PMID 9224655.
- Eggermont J (1998). "The exon-intron architecture of human chloride channel genes is not conserved". Biochim. Biophys. Acta 1397 (2): 156–60. doi:10.1016/s0167-4781(98)00014-1. PMID 9565675.
- "Expression of CLCN voltage-gated chloride channel genes in human blood vessels". J. Mol. Cell. Cardiol. 31 (3): 657–66. 1999. doi:10.1006/jmcc.1998.0901. PMID 10198195.
- "Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1)". Biochim. Biophys. Acta 1447 (1): 100–6. 1999. doi:10.1016/s0167-4781(99)00128-1. PMID 10500249.
- "Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium". Am. J. Respir. Cell Mol. Biol. 24 (4): 376–81. 2001. doi:10.1165/ajrcmb.24.4.4114. PMID 11306429.
- "Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms". Mamm. Genome 13 (9): 483–92. 2003. doi:10.1007/s00335-002-2167-6. PMID 12370778.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
External links
- CLCN6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CLCN6 genome location and CLCN6 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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