Chemistry:Clofluperol

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Clofluperol is a neuroleptic tranquilizer of the butyrophenone class.[1][2][3] It has the same aromatic piperidinol moiety that is present in penfluridol and fluperamide. The structure can be seen to be a sort of hybrid between that of trifluperidol and haloperidol.

References

  1. ↑ "[Long-acting neuroleptics. I. Pilot study of clofluperol (R9298)]" (in French). Acta Neurologica et Psychiatrica Belgica 68 (2): 128–136. February 1968. PMID 4972601. 
  2. ↑ "The distribution of the butyrophenones haloperidol, trifluperidol, moperone, and clofluperol in rats, and its relationship with their neuroleptic activity". Arzneimittel-Forschung 19 (2): 199–208. February 1969. PMID 5818759. 
  3. ↑ "Sulman FG: Mammotropic and neuroleptic effects of butyrophenones in the rat". Archives Internationales de Pharmacodynamie et de Therapie 179 (1): 94–105. May 1969. PMID 5388566. 



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