Chemistry:GR-159897
From HandWiki
Short description: Chemical compound
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| Formula | C23H27FN2O2S |
| Molar mass | 414.54 g·mol−1 |
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GR-159897 is a potent and selective NK2 receptor antagonist drug.[1] It has anxiolytic effects in animal models,[2] and also inhibits bronchoconstriction of the airways, which may potentially make it useful in the treatment of asthma.[3][4]
See also
References
- ↑ "GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors". European Journal of Pharmacology 272 (2–3): 241–8. January 1995. doi:10.1016/0014-2999(94)00655-q. PMID 7713168.
- ↑ "The anxiolytic-like activity of GR159897, a non-peptide NK2 receptor antagonist, in rodent and primate models of anxiety". Psychopharmacology 121 (2): 186–91. September 1995. doi:10.1007/bf02245629. PMID 8545524.
- ↑ "Tachykinin NK2 receptors further characterized in the lung with nonpeptide receptor antagonists". Canadian Journal of Physiology and Pharmacology 73 (7): 878–84. July 1995. doi:10.1139/y95-121. PMID 8846425.
- ↑ "Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells". American Journal of Physiology. Lung Cellular and Molecular Physiology 294 (3): L523-34. March 2008. doi:10.1152/ajplung.00328.2007. PMID 18203813.
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