Chemistry:ML398
From HandWiki
ML398 is a potent and selective dopamine D4 receptor antagonist which has been used in scientific research.[1][2][3] It shows high affinity for the dopamine D4 receptor (Ki = 36 nM) and negligible affinity for other four dopamine receptors (>20,000 nM).[2][3] As such, the drug shows more than 100-fold selectivity for the dopamine D4 receptor over the other dopamine receptors.[2][3] It has been found to reverse cocaine-induced hyperlocomotion.[2] The chemical synthesis of ML398 has been described.[2][4] ML398 was first described in the scientific literature by 2014.[2]
References
- ↑ "Delving into the Latest Updates on ML-398 with Synapse". 23 May 2026. https://synapse.patsnap.com/drug/00c210ec280748648afc147640c07d99.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity". ACS Medicinal Chemistry Letters 5 (9): 1060–1064. September 2014. doi:10.1021/ml500267c. PMID 25221667.
- ↑ 3.0 3.1 3.2 "Discovery and characterization of ML398, a potent and selective chiral morpholine based antagonist of the dopamine 4 (D4) receptor". Probe Reports from the NIH Molecular Libraries Program. 2015. PMID 25834901.
- ↑ "A Concise Stereoselective Synthesis of ( R )-2-Benzylmorpholine and ML398 from ( R )-(−)-2-Phenylglycinol". Journal of Heterocyclic Chemistry 56 (9): 2677–2682. 2019. doi:10.1002/jhet.3657. ISSN 0022-152X.
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