Chemistry:O-4210
From HandWiki
Short description: Chemical compound
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| Formula | C17H18FNOS |
| Molar mass | 303.394 g·mol−1 |
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O-4210 is a drug developed by Organix Inc which acts as a selective dopamine reuptake inhibitor, with good selectivity over the serotonin transporter but its activity at the noradrenaline transporter is not known. It is a thiatropane derivative, related in chemical structure to phenyltropane derivatives such as RTI-126 and RTI-171, but with the amine nitrogen replaced by sulfur, demonstrating that this nitrogen only plays a minor contribution to receptor binding, in a similar manner to the related oxatropane tropoxane.[1][2]
See also
- List of phenyltropanes
References
- ↑ "Synthesis of 8-thiabicyclo[3.2.1octanes and their binding affinity for the dopamine and serotonin transporters"]. Bioorganic & Medicinal Chemistry 15 (2): 1067–82. January 2007. doi:10.1016/j.bmc.2006.10.016. PMID 17070057.
- ↑ "The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1octanes"]. Bioorganic & Medicinal Chemistry Letters 21 (1): 48–51. January 2011. doi:10.1016/j.bmcl.2010.11.076. PMID 21146984.
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