Chemistry:Bay K8644
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Names | |
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Preferred IUPAC name
Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate | |
Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
EC Number |
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PubChem CID
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Properties | |
C16H15F3N2O4 | |
Molar mass | 356.301 g·mol−1 |
Insoluble | |
Solubility in other solvents | DMSO: 184 mg/mL; methanol and ethanol: 63 mg/mL |
Hazards | |
GHS pictograms | ![]() |
GHS Signal word | Warning |
H315, H319 | |
P264, P280, P302+352, P305+351+338, P321, P332+313, P337+313, P362 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Infobox references | |
Tracking categories (test):
Bay K8644 is a chemical compound that functions as an L-type calcium channel agonist. Bay K8644 is used primarily as a biochemical research tool for this effect.[2] It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.
Mechanism of action
Bay K8644 targets L-type voltage-gated calcium channels. It is the first positive inotropic agent shown to act specifically and directly on calcium channels.[3]
References
- ↑ (±)-Bay K8644 at Sigma-Aldrich
- ↑ CID 2303 from PubChem
- ↑ Thomas, G; Chung, M; Cohen, CJ (January 1985). "A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent.". Circ Res 56 (1): 87–96. doi:10.1161/01.res.56.1.87. PMID 2578336.
![]() | Original source: https://en.wikipedia.org/wiki/Bay K8644.
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