Biology:Cyclic nucleotide-gated channel alpha 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein.[1] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium.[2] In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio.[3][4][5] The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current.[6] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.
See also
- Cyclic nucleotide-gated ion channel
References
- ↑ "Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1259.
- ↑ Kaupp, U. Benjamin; Niidome, Tetsuhiro; Tanabe, Tsutomu; Terada, Shoichi; Bönigk, Wolfgang; Stühmer, Walter; Cook, Neil J.; Kangawa, Kenji et al. (December 1989). "Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel". Nature 342 (6251): 762–766. doi:10.1038/342762a0. ISSN 0028-0836. PMID 2481236. Bibcode: 1989Natur.342..762K.
- ↑ Zheng, Jie; Trudeau, Matthew C.; Zagotta, William N. (December 2002). "Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit". Neuron 36 (5): 891–896. doi:10.1016/s0896-6273(02)01099-1. ISSN 0896-6273. PMID 12467592.
- ↑ Zhong, Haining; Molday, Laurie L.; Molday, Robert S.; Yau, King-Wai (November 2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry". Nature 420 (6912): 193–198. doi:10.1038/nature01201. ISSN 0028-0836. PMID 12432397. Bibcode: 2002Natur.420..193Z.
- ↑ Weitz, Dietmar; Ficek, Nicole; Kremmer, Elisabeth; Bauer, Paul J.; Kaupp, U.Benjamin (December 2002). "Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors". Neuron 36 (5): 881–889. doi:10.1016/s0896-6273(02)01098-x. ISSN 0896-6273. PMID 12467591.
- ↑ Chen, T.-Y.; Peng, Y.-W.; Dhallan, R. S.; Ahamed, B.; Reed, R. R.; Yau, K.-W. (April 1993). "A new subunit of the cyclic nucleotide-gated cation channel in retinal rods". Nature 362 (6422): 764–767. doi:10.1038/362764a0. ISSN 0028-0836. PMID 7682292. Bibcode: 1993Natur.362..764C.
Further reading
- "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews 57 (4): 455–62. December 2005. doi:10.1124/pr.57.4.8. PMID 16382102.
- "Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel". The Journal of Biological Chemistry 267 (9): 6257–62. March 1992. doi:10.1016/S0021-9258(18)42689-0. PMID 1372902.
- "Identification and characterization of a partial cDNA expressing interleukin-1-like activity in keratinocytes". Molecular Immunology 29 (3): 431–8. March 1992. doi:10.1016/0161-5890(92)90031-R. PMID 1372959.
- "Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression". The Journal of Neuroscience 12 (8): 3248–56. August 1992. doi:10.1523/JNEUROSCI.12-08-03248.1992. PMID 1379636.
- "Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa". Proceedings of the National Academy of Sciences of the United States of America 92 (22): 10177–81. October 1995. doi:10.1073/pnas.92.22.10177. PMID 7479749. Bibcode: 1995PNAS...9210177D.
- "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells". Neuropharmacology 33 (11): 1275–82. November 1994. doi:10.1016/0028-3908(94)90027-2. PMID 7532814. https://epub.ub.uni-muenchen.de/3654/1/3654.pdf.
- "Human rod cGMP-gated cation channel gene maps to 4p12-->centromere by chromosomal in situ hybridization". Genomics 16 (1): 302–3. April 1993. doi:10.1006/geno.1993.1187. PMID 7683629.
- "Generation and analysis of 280,000 human expressed sequence tags". Genome Research 6 (9): 807–28. September 1996. doi:10.1101/gr.6.9.807. PMID 8889549.
- "Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa". Journal of Medical Genetics 39 (10): 66e–66. October 2002. doi:10.1136/jmg.39.10.e66. PMID 12362048.
- "An endogenous RNA transcript antisense to CNG(alpha)1 cation channel mRNA". Molecular Biology of the Cell 13 (10): 3696–705. October 2002. doi:10.1091/mbc.E02-03-0127. PMID 12388767.
- "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry". Nature 420 (6912): 193–8. November 2002. doi:10.1038/nature01201. PMID 12432397. Bibcode: 2002Natur.420..193Z.
- "Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit". Neuron 36 (5): 891–6. December 2002. doi:10.1016/S0896-6273(02)01099-1. PMID 12467592.
- "Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs". Biochemistry 42 (15): 4593–600. April 2003. doi:10.1021/bi027276z. PMID 12693957. http://juser.fz-juelich.de/record/30216/files/27726.pdf.
- "Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation". Molecular Vision 10: 884–9. November 2004. PMID 15570217.
- "Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis". Journal of Andrology 26 (2): 258–63. 2005. doi:10.1002/j.1939-4640.2005.tb01093.x. PMID 15713832.
External links
- GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview
- CNGA1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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