Biology:KCNK7
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which is encoded in humans by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains.[1][2][3] Multiple transcript variants encoding different isoforms have been found for this gene.[4]
Function
This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.[4]
See also
- Tandem pore domain potassium channel
References
- ↑ "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. April 1999. doi:10.1074/jbc.274.17.11751. PMID 10206991.
- ↑ "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. March 2001. doi:10.1038/35058574. PMID 11256078. https://escholarship.org/uc/item/9z7112ns.
- ↑ "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. December 2005. doi:10.1124/pr.57.4.12. PMID 16382106. https://escholarship.org/uc/item/3k15p5vt.
- ↑ 4.0 4.1 "Entrez Gene: potassium channel". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10089.
Further reading
- Strausberg RL; Feingold EA; Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. 2001. doi:10.1038/35058574. PMID 11256078. https://escholarship.org/uc/item/9z7112ns.
- Salinas M; Reyes R; Lesage F et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
- Medhurst AD; Rennie G; Chapman CG et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery". Brain Res. Mol. Brain Res. 86 (1–2): 101–14. doi:10.1016/S0169-328X(00)00263-1. PMID 11165377.
External links
- KCNK7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- KCNK7 human gene location in the UCSC Genome Browser.
- KCNK7 human gene details in the UCSC Genome Browser.
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