Biology:Aquaporin-9
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Aquaporin-9 (AQP-9) is a protein that in humans is encoded by the AQP9 gene.[1]
The aquaporins/major intrinsic protein are a family of water-selective membrane channels. Aquaporin-9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin-9 allows passage of a wide variety of noncharged solutes. AQP-9 stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. Aquaporin-9 may also have some role in specialized leukocyte functions such as immunological response and bactericidal activity.[1]
References
Further reading
- "Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol". Biochem. Biophys. Res. Commun. 244 (1): 268–74. 1998. doi:10.1006/bbrc.1998.8252. PMID 9514918.
- "Molecular characterization of a broad selectivity neutral solute channel". J. Biol. Chem. 273 (38): 24737–43. 1998. doi:10.1074/jbc.273.38.24737. PMID 9733774.
- "Functional and molecular characterization of the human neutral solute channel aquaporin-9". Am. J. Physiol. 277 (5 Pt 2): F685–96. 1999. doi:10.1152/ajprenal.1999.277.5.F685. PMID 10564231.
- "Aquaporin 9 expression along the male reproductive tract". Biol. Reprod. 65 (2): 384–93. 2001. doi:10.1095/biolreprod65.2.384. PMID 11466204.
- "Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta". Placenta 22 (8–9): 776–81. 2001. doi:10.1053/plac.2001.0717. PMID 11597198.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine". FEBS Lett. 540 (1–3): 157–62. 2003. doi:10.1016/S0014-5793(03)00256-4. PMID 12681500.
- "Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9". Biochem. Biophys. Res. Commun. 322 (3): 836–41. 2004. doi:10.1016/j.bbrc.2004.08.002. PMID 15336539.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Expression of aquaporin 9 in human chorioamniotic membranes and placenta". Am. J. Obstet. Gynecol. 191 (6): 2160–7. 2005. doi:10.1016/j.ajog.2004.05.089. PMID 15592307.
- "Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas". Placenta 27 (11–12): 1073–81. 2006. doi:10.1016/j.placenta.2005.11.014. PMID 16480766.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Filopodia are induced by aquaporin-9 expression". Exp. Cell Res. 313 (7): 1295–306. 2007. doi:10.1016/j.yexcr.2007.01.023. PMID 17346701.
- "Expression of the water channel protein aquaporin-9 in malignant brain tumors". Appl. Immunohistochem. Mol. Morphol. 15 (2): 193–8. 2007. doi:10.1097/01.pai.0000213110.05108.e9. PMID 17525633.
External links
- AQP9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human AQP9 genome location and AQP9 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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