Chemistry:5-Hydroxyindoline
From HandWiki
5-Hydroxyindoline, also known as 2,3-dihydro-1H-indol-5-ol, is a psychoactive substance, saturated (hydrogenated) derivative of indole, which has a hydroxyl group in the 5th position of the benzene ring, structurally belong to the family of indoline derivatives.
Pharmacology
5-Hydroxyindoline has shown superior results as a dopamine D4 receptor ligand, with more selective binding than classical dopaminergic drugs. It is a D4 receptor agonist.[1]
Other studies have shown that 5-hydroxyindoline is an inhibitor of the D2 dopamine receptor.[2]
Occurrence
5-Hydroxyindoline was found and isolated from Phoebe chekiangensis.[1]
References
- ↑ 1.0 1.1 Hegde, Vinod R.; Dai, Ping; Ladislaw, Christine; Patel, Mahesh G.; Puar, Mohindar S.; Pachter, Jonathan A. (1997-05-06). "D4 dopamine receptor-selective compounds from the Chinese plant Phoebe chekiangensis". Bioorganic & Medicinal Chemistry Letters 7 (9): 1207–1212. doi:10.1016/S0960-894X(97)00194-7. ISSN 0960-894X. https://www.sciencedirect.com/science/article/pii/S0960894X97001947.
- ↑ "AID 61307 - Inhibitory concentration against binding of [3Hspiperone to human D2 dopaminergic receptor - PubChem"]. https://pubchem.ncbi.nlm.nih.gov/bioassay/61307.
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