Chemistry:Alpha-GPC
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| Formula | C8H20NO6P |
| Molar mass | 257.223 g·mol−1 |
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L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor[1] which has been investigated for its potential for the treatment of Alzheimer's disease[2] and other dementias.[3]
Alpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of acetylcholine.[2] It is a non-prescription drug in most countries. The FDA determined that intake of no more than 196.2 mg/person/day is considered generally recognized as safe (GRAS).[4]
Production
Industrially, alpha-GPC is produced by the chemical or enzymatic deacylation of phosphatidylcholine enriched soya phospholipids followed by chromatographic purification. Alpha-GPC may also be derived in small amounts from highly purified soy lecithin as well as from purified sunflower lecithin.[citation needed]
References
- ↑ "Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial". Clinical Therapeutics 25 (1): 178–93. January 2003. doi:10.1016/S0149-2918(03)90023-3. PMID 12637119.
- ↑ 2.0 2.1 "Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation?". Journal of the Neurological Sciences 257 (1–2): 264–9. June 2007. doi:10.1016/j.jns.2007.01.043. PMID 17331541.
- ↑ "Treatment of dementia with neurotransmission modulation". Expert Opinion on Investigational Drugs 12 (10): 1633–54. October 2003. doi:10.1517/13543784.12.10.1633. PMID 14519085.
- ↑ "Generally Recognized as Safe (GRAS) Determination for the Use of AlphaSize® Alpha-Glycerylphosphoryl Choline". United States Food and Drug Administration. 25 January 2012. https://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000419.pdf.
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