Chemistry:Coriamyrtin

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Coriamyrtin is a toxic γ-lactone naturally present in a multitude of plants.

Natural occurrence

Coriamyrtin can be found in Scurrula parasitica,[1] Coriaria microphylla,[2] Coriaria nepalensis,[3] and certain other plants.

Toxicity

Coriamyrtin is a convulsant.[4] It appears to act via antagonism of GABAA receptors.[5] Poisoning is usually from ingestion of parts of the plants containing it. A case of poisoning was able to be treated with repeated administration of diazepam, an anticonvulsant.[3]

References

  1. ↑ PubChem. "Scurrula parasitica" (in en). https://pubchem.ncbi.nlm.nih.gov/taxonomy/Scurrula-parasitica. 
  2. ↑ PubChem. "Coriaria microphylla" (in en). https://pubchem.ncbi.nlm.nih.gov/taxonomy/Coriaria-microphylla. 
  3. ↑ 3.0 3.1 De Haro, Luc; Pommier, Philip; Tichadou, Lucia; Hayek-Lanthois, Maryvonne; Arditti, Jocelyne (2005). "Poisoning by Coriaria myrtifolia Linnaeus: A new case report and review of the literature". Toxicon 46 (6): 600–603. doi:10.1016/j.toxicon.2005.06.026. PMID 16165183. Bibcode: 2005Txcn...46..600D. 
  4. ↑ "T3DB: Coriamyrtin". http://www.t3db.ca/toxins/T3D4074. 
  5. ↑ Pérez, Claudia; Becerra, José; Manríquez-Navarro, Paula; Aguayo, Luis Gerardo; Fuentealba, Jorge; Guzmán, José Leonardo; Joseph-Nathan, Pedro; Jiménez, Verónica et al. (2011). "Inhibitory activities on mammalian central nervous system receptors and computational studies of three sesquiterpene lactones from Coriaria ruscifolia subsp. ruscifolia". Chemical & Pharmaceutical Bulletin 59 (2): 161–165. doi:10.1248/cpb.59.161. ISSN 1347-5223. PMID 21297293. 

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GABAB
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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

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