Chemistry:Fengabine
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Short description: Chemical compound
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| Routes of administration | Oral |
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| Formula | C17H17Cl2NO |
| Molar mass | 322.23 g·mol−1 |
Fengabine (SL-79,229) is a drug which was investigated as an antidepressant but was never marketed.[1][2] Its mechanism of action is unknown, but its antidepressant effects are reversed by GABAA receptor antagonists like bicuculline and it has hence been labeled as GABAergic; however, it does not actually bind to GABA receptors, nor does it inhibit GABA-T.[1][2] In clinical trials, fengabine's efficacy was comparable to that of the tricyclic antidepressants, but with a more rapid onset of action and much less side effects.[3][4][5] Notably, fengabine lacks any sedative effects.[4]
See also
References
- ↑ 1.0 1.1 "Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile". The Journal of Pharmacology and Experimental Therapeutics 241 (1): 245–50. April 1987. PMID 3033203. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=3033203.
- ↑ 2.0 2.1 "Fengabine, a novel antidepressant GABAergic agent. II. Effect on cerebral noradrenergic, serotonergic and GABAergic transmission in the rat". The Journal of Pharmacology and Experimental Therapeutics 241 (1): 251–7. April 1987. PMID 3033204. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=3033204.
- ↑ "Fengabine, a new GABAmimetic agent in the treatment of depressive disorders: an overview of six double-blind studies versus tricyclics". Neuropsychobiology 20 (3): 126–31. 1989. doi:10.1159/000118485. PMID 2668780.
- ↑ 4.0 4.1 "Therapeutic effects of fengabine, a new GABAergic agent, in depressed outpatients: a double-blind study versus clomipramine". Acta Psychiatrica Scandinavica 82 (5): 366–71. November 1990. doi:10.1111/j.1600-0447.1990.tb01402.x. PMID 2281807.
- ↑ "A placebo controlled double-blind evaluation of the pharmacodynamics of fengabine vs amitriptyline following single and multiple doses in elderly volunteers". British Journal of Clinical Pharmacology 35 (3): 278–83. March 1993. doi:10.1111/j.1365-2125.1993.tb05695.x. PMID 8471403.
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