Chemistry:Flindokalner

From HandWiki

Flindokalner (BMS-204352, MaxiPost) is a drug which acts as an opener of BKCa large-conductance, calcium-activated potassium channels. It was unsuccessful in clinical trials as a potential treatment for stroke, but continues to be researched for other applications such as Fragile X syndrome.[1][2][3][4][5][6][7][8][9]

See also

References

  1. ↑ "Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels". Nature Medicine 7 (4): 471–477. April 2001. doi:10.1038/86546. PMID 11283675. 
  2. ↑ "BMS-204352: a potassium channel opener developed for the treatment of stroke". CNS Drug Reviews 8 (4): 353–360. 2002. doi:10.1111/j.1527-3458.2002.tb00233.x. PMID 12481191. 
  3. ↑ "Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle". Naunyn-Schmiedeberg's Archives of Pharmacology 369 (5): 481–489. May 2004. doi:10.1007/s00210-004-0920-y. PMID 15095032. 
  4. ↑ "Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels". The Journal of Pharmacology and Experimental Therapeutics 314 (1): 282–292. July 2005. doi:10.1124/jpet.105.083923. PMID 15814569. 
  5. ↑ "Association of a functional deficit of the BKCa channel, a synaptic regulator of neuronal excitability, with autism and mental retardation". The American Journal of Psychiatry 163 (9): 1622–1629. September 2006. doi:10.1176/ajp.2006.163.9.1622. PMID 16946189. 
  6. ↑ "BK channel modulators: a comprehensive overview". Current Medicinal Chemistry 15 (11): 1126–1146. 2008. doi:10.2174/092986708784221412. PMID 18473808. 
  7. ↑ "Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule". Orphanet Journal of Rare Diseases 9. 1 August 2014. doi:10.1186/s13023-014-0124-6. PMID 25079250. 
  8. ↑ "Potential Involvement of Impaired BKCa Channel Function in Sensory Defensiveness and Some Behavioral Disturbances Induced by Unfamiliar Environment in a Mouse Model of Fragile X Syndrome". Neuropsychopharmacology 43 (3): 492–502. February 2018. doi:10.1038/npp.2017.149. PMID 28722023. 
  9. ↑ "Reversal of cell, circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy". Nature Communications 14 (1). 30 August 2023. doi:10.1038/s41467-023-41035-w. PMID 37648685. Bibcode: 2023NatCo..14.5285B. 



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