Chemistry:CLCA3
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Chloride channel accessory 3, also known as CLCA3, is a protein which in humans is encoded by the CLCA3P pseudogene. The protein encoded by this gene is a chloride channel.[1] According to the HGNC, this protein is not expressed in humans but is in certain other species such as mouse. However, some conflicting reports state that human cells produce and glycosylate this protein.[1]
Function
This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD), although this gene is translated into a well characterized protein which has been shown to decorate mucin granule containing vesicles. Protein structure prediction methods suggest the N-terminal region of CLCA3 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[2]
See also
References
- ↑ 1.0 1.1 "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels". Biochimica et Biophysica Acta 1444 (3): 418–23. March 1999. doi:10.1016/S0167-4781(99)00008-1. PMID 10095065.
- ↑ "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins 63 (3): 424–39. May 2006. doi:10.1002/prot.20887. PMID 16470849.
Further reading
- "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proceedings of the National Academy of Sciences of the United States of America 97 (9): 4832–7. April 2000. doi:10.1073/pnas.090521697. PMID 10758170. Bibcode: 2000PNAS...97.4832L.
- "Molecular characteristics and functional diversity of CLCA family members". Clinical and Experimental Pharmacology & Physiology 27 (11): 901–5. November 2000. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307.
- "Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31)". Genome 42 (5): 1030–2. October 1999. doi:10.1139/gen-42-5-1030. PMID 10584316.
External links
- CLCA3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/CLCA3.
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