Chemistry:Bufenadrine

From HandWiki

Bufenadrine (INN; developmental code name B.S. 6534), also known as 2-tert-butyldiphenhydramine, is a drug described as an antiemetic, antihistamine, anticholinergic, and antiparkinsonian agent which was never marketed.[1][2][3][4] It is the 2-tert-butyl analogue of diphenhydramine.[2] The drug was found to produce stereoselective hepatotoxicity in animals and this led to the discontinuation of its development.[2][5] Bufenadrine was first described in the literature by 1967.[1][4] Its INN suffix "-drine" is generally for sympathomimetics but bufenadrine itself is not actually a sympathomimetic or related agent.[6]

References

  1. ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. 2014. p. 186. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA186. Retrieved 17 October 2024. 
  2. ↑ 2.0 2.1 2.2 Stereochemical Aspects of Drug Action and Disposition. Handbook of Experimental Pharmacology. Springer Berlin Heidelberg. 2012. p. 422. ISBN 978-3-642-55842-9. https://books.google.com/books?id=0U_xCAAAQBAJ&pg=PA422. Retrieved 17 October 2024. 
  3. ↑ Drug Design: Medicinal Chemistry: A Series of Monographs, Vol. 6. Academic Press. 2013. p. 12. ISBN 978-1-4832-1608-9. https://books.google.com/books?id=PQwlBQAAQBAJ&pg=PA12. Retrieved 17 October 2024. 
  4. ↑ 4.0 4.1 Pharmaceutical Manufacturing Encyclopedia. Volumes 1-4. William Andrew Publishing. 2013. pp. 704–705. ISBN 978-0-8155-1856-3. https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA704. Retrieved 17 October 2024. 
  5. ↑ "Differences in metabolic behavior and liver toxicity between the optical isomers of bufenadrine hydrochloride, a substituted diphenhydramine, in the rat". Acta Pharmacol Toxicol (Copenh) 31 (5): 369–379. 1972. doi:10.1111/j.1600-0773.1972.tb03600.x. PMID 4678820. 
  6. ↑ "-drine sympathomimetics". The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2018 (Stem Book 2018). World Health Organization. https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/stembook-2018.pdf#page=95. 



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