Biology:ITPR1

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Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.^[1]^[2]^[3]^[4]^[5]

Interactions

ITPR1 has been shown to interact with:

AHCYL1,^[6]
CA8,^[7]
EPB41L1^[8]
FKBP1A,^[9]^[10]
MRVI1,^[11]
PRKG1,^[11]
RHOA,^[12] and
TRPC4.^[13]^[14]

Caspr2, ^[15]

See also

Inositol triphosphate
Inositol triphosphate receptor

References

↑ "Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization". The Biochemical Journal 302 (Pt 3): 781–90. Sep 1994. doi:10.1042/bj3020781. PMID 7945203.
↑ "Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant". Brain Research. Molecular Brain Research 32 (2): 291–6. Sep 1995. doi:10.1016/0169-328X(95)00089-B. PMID 7500840.
↑ "Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans". PLOS Genetics 3 (6): e108. Jun 2007. doi:10.1371/journal.pgen.0030108. PMID 17590087.
↑ "Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16". Journal of Medical Genetics 45 (1): 32–5. Jan 2008. doi:10.1136/jmg.2007.053942. PMID 17932120.
↑ "Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3708.
↑ "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". The Journal of Biological Chemistry 278 (12): 10602–12. Mar 2003. doi:10.1074/jbc.M210119200. PMID 12525476.
↑ "Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1". The Biochemical Journal 372 (Pt 2): 435–41. Jun 2003. doi:10.1042/BJ20030110. PMID 12611586.
↑ "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Molecular and Cellular Neurosciences 22 (2): 271–83. Feb 2003. doi:10.1016/s1044-7431(02)00027-1. PMID 12676536.
↑ "In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin". Journal of Cell Science 118 (Pt 23): 5443–51. Dec 2005. doi:10.1242/jcs.02657. PMID 16278292.
↑ "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain". The Journal of Biological Chemistry 272 (44): 27582–8. Oct 1997. doi:10.1074/jbc.272.44.27582. PMID 9346894.
↑ ^11.0 ^11.1 "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature 404 (6774): 197–201. Mar 2000. doi:10.1038/35004606. PMID 10724174. Bibcode: 2000Natur.404..197S.
↑ "RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability". The Journal of Biological Chemistry 278 (35): 33492–500. Aug 2003. doi:10.1074/jbc.M302401200. PMID 12766172.
↑ "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell 114 (6): 777–89. Sep 2003. doi:10.1016/s0092-8674(03)00716-5. PMID 14505576.
↑ "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors". FEBS Letters 487 (3): 377–83. Jan 2001. doi:10.1016/s0014-5793(00)02362-0. PMID 11163362.
↑ "Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulatesPurkinje cell morphology". The Journal of Biological Chemistry 295 (36): 12716–26. Sep 2020. doi:10.1074/jbc.RA120.012655. PMID 32675284.

Further reading

"Modelling thymic HIV-1 Nef effects". Current HIV Research 4 (1): 57–64. Jan 2006. doi:10.2174/157016206775197583. PMID 16454711.
"Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells". The Journal of Biological Chemistry 270 (40): 23310–6. Oct 1995. doi:10.1074/jbc.270.40.23310. PMID 7559486.
"The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation". The Journal of Biological Chemistry 270 (6): 2833–40. Feb 1995. doi:10.1074/jbc.270.6.2833. PMID 7852357.
"Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation". The Journal of Biological Chemistry 269 (11): 7963–9. Mar 1994. doi:10.1016/S0021-9258(17)37145-4. PMID 8132516.
"Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry 269 (12): 8701–7. Mar 1994. doi:10.1016/S0021-9258(17)37024-2. PMID 8132598.
"Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux". Cell 83 (3): 463–72. Nov 1995. doi:10.1016/0092-8674(95)90124-8. PMID 8521476.
"Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation". International Journal of Radiation Biology 69 (5): 539–46. May 1996. doi:10.1080/095530096145544. PMID 8648241.
"Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets". Biochemical and Biophysical Research Communications 224 (3): 740–6. Jul 1996. doi:10.1006/bbrc.1996.1093. PMID 8713116.
"FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain". The Journal of Biological Chemistry 272 (44): 27582–8. Oct 1997. doi:10.1074/jbc.272.44.27582. PMID 9346894.
"The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor". Gene 207 (2): 219–25. Jan 1998. doi:10.1016/S0378-1119(97)00630-6. PMID 9511764.
"Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum". Neuroscience 85 (1): 205–16. Jul 1998. doi:10.1016/S0306-4522(97)00612-X. PMID 9607712.
"Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron 21 (4): 717–26. Oct 1998. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
"Functional interaction between InsP3 receptors and store-operated Htrp3 channels". Nature 396 (6710): 478–82. Dec 1998. doi:10.1038/24890. PMID 9853757. Bibcode: 1998Natur.396..478K.
"Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi". The Journal of Cell Biology 145 (2): 279–89. Apr 1999. doi:10.1083/jcb.145.2.279. PMID 10209024.
"Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature 404 (6774): 197–201. Mar 2000. doi:10.1038/35004606. PMID 10724174. Bibcode: 2000Natur.404..197S.
"Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. Mar 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
"Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". Journal of Immunology 164 (12): 6538–42. Jun 2000. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
"Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins". The Journal of Biological Chemistry 275 (35): 27488–93. Sep 2000. doi:10.1074/jbc.M004495200. PMID 10874040.

External links

ITPR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 15

v t e PDB gallery
1n4k: Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3 1xzz: Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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