Chemistry:Dimetindene
From HandWiki
Short description: Chemical compound
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| Trade names | Fenistil |
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| Routes of administration | Oral, topical |
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| Formula | C20H24N2 |
| Molar mass | 292.426 g·mol−1 |
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| Chirality | Racemic mixture |
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Dimetindene , also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation[1] selective H1 antagonist.[2] Dimetindene is an atypical first generation H1 antagonist as it only minimally[3] passes across the blood–brain barrier.
Dimetindene is also an M2 receptor antagonist.[4]
It was patented in 1958 and came into medical use in 1960.[5]
Medical use
Dimetindene is used orally and topically as an antipruritic.[6] It is used topically to treat skin irritations, such as insect bites. Dimetindene is also administered orally to treat allergies, such as hay fever.
It is commonly formulated as its maleic acid salt, dimethindene maleate.
Names
It is sold under the brand name Fenistil among others.
References
- ↑ "Assessment of Patient Attitudes About Mometasone Furoate Nasal Spray: The Ease-of-Use Patient Survey". The World Allergy Organization Journal 1 (9): 156–159. September 2008. doi:10.1186/1939-4551-1-9-145. PMID 23282579.
- ↑ "Dimetindene". https://www.drugs.com/international/dimetindene.html.
- ↑ "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior 51 (6): 1123–1127. June 1992. doi:10.1016/0031-9384(92)90297-f. PMID 1353628.
- ↑ "Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats". Urology 75 (4): 862–867. April 2010. doi:10.1016/j.urology.2009.12.013. PMID 20156651.
- ↑ (in en) Analogue-based Drug Discovery. John Wiley & Sons. 2006. p. 547. ISBN 9783527607495. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA547.
- ↑ "A clinical evaluation of dimethindene". Current Therapeutic Research, Clinical and Experimental 4: 306–309. June 1962. PMID 14006402.
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