Chemistry:3-Thioescaline
3-Thioescaline (3-TE), also known as 3-methoxy-4-ethoxy-5-methylthiophenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline.[1][2][3][4] It is the analogue of escaline in which the methoxy group at the 3 position has been replaced with a methylthio group.[1][2][3][4] The drug is one of two possible thioescaline (TE) positional isomers, the other being 4-thioescaline (4-TE).[1][2][3][4]
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 3-thioescaline's dose as 60 to 80 mg orally and its duration as 8 to 12 hours.[1][2][3] The drug has approximately 5 or 6 times the potency of mescaline.[2][3][4][1] The effects of 3-thioescaline have been reported to include closed-eye imagery and fantasy, sounds having a deeper pitch, introspection, enhanced appreciation of art and music, time dilation, body load, and sleep disturbances.[1] It was said to be psychedelic rather than just intoxicating.[1] The desired psychoactive effects were said to outweigh its physical side effects.[1]
The chemical synthesis of 3-thioescaline has been described.[1][4]
3-Thioescaline was first described in the scientific literature by Alexander Shulgin and Peyton Jacob III in 1984.[4] Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.[1]
See also
- Scaline
- 4-Thioescaline
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml. https://erowid.org/library/books_online/pihkal/pihkal150.shtml
- ↑ 2.0 2.1 2.2 2.3 2.4 "Structure-Activity Relationships of the Classic Hallucinogens and Their Analogs". Hallucinogens: An Update. National Institute on Drug Abuse Research Monograph Series. 146. National Institute on Drug Abuse. 1994. pp. 74–91. https://bibliography.maps.org/resources/download/11534.
- ↑ 3.0 3.1 3.2 3.3 3.4 "Basic Pharmacology and Effects". Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. 2003. pp. 67–137. ISBN 978-0-12-433951-4. https://bibliography.maps.org/resources/download/12634.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 "Sulfur analogues of psychotomimetic agents. 3. Ethyl homologues of mescaline and their monothio analogues". J Med Chem 27 (7): 881–888. July 1984. doi:10.1021/jm00373a013. PMID 6737431.
External links
- 3-TE (3-Thioescaline) - Isomer Design
- 3-TE (3-Thioescaline) - PiHKAL - Erowid
- 3-TE (3-Thioescaline) - PiHKAL - Isomer Design
 |  |
