Chemistry:N,alpha-Diethylphenylethylamine
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| Other names | N,α-DEPEA |
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| Formula | C12H19N |
| Molar mass | 177.291 g·mol−1 |
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N,α-Diethylphenylethylamine (N,α-DEPEA, 2-ethylamino-1-phenylbutane, EAPB) is a close chemical analog of methamphetamine, which has been sold as a designer drug.[1][2][3] It was originally patented by Knoll Pharma as one of several analogs for pharmaceutical applications. In animals models these analogs showed properties of cognitive enhancement and increased pain tolerance.[4] Nevertheless, this class of compounds was never developed into a medicine. N,α-DEPEA has not been studied in humans, but experts such as Pieter Cohen of Harvard Medical School expect it to be less potent than methamphetamine, but greater than ephedrine.[5]
Adulterant in nutritional supplements
In January 2013, the Korean authorities reported seizing a large quantity of the pure material, predicting it would soon be found on the market.[6] Later in 2013, it was found as an adulterant in biologically significant amounts in the pre-workout supplements Craze (marketed by Driven Sports, Inc.) and Detonate (marketed by Gaspari Nutrition).[4][7] It was falsely claimed to be Dendrobium extract.[5][8][9]
See also
- Buphedrone
- Butylone
- EBDB
- Etilamfetamine
- Eutylone
- N-Ethylbuphedrone
- Phenylisobutylamine
References
- ↑ "Determination of designer doping agent--2-ethylamino-1-phenylbutane--in dietary supplements and excretion study following single oral supplement dose". Journal of Pharmaceutical and Biomedical Analysis 115: 523–33. November 2015. doi:10.1016/j.jpba.2015.07.025. PMID 26311473.
- ↑ "Designer phenethylamines routinely found in human urine: 2-ethylamino-1-phenylbutane and 2-amino-1-phenylbutane". Journal of Analytical Toxicology 38 (2): 106–9. March 2014. doi:10.1093/jat/bkt121. PMID 24451085.
- ↑ "2-Ethylamino-1-phenylbutane". Cayman Chemical. https://www.caymanchem.com/app/template/Product.vm/catalog/9001863.
- ↑ 4.0 4.1 "Identification and quantitation of N,α-diethylphenethylamine in preworkout supplements sold via the Internet". Forensic Toxicology 32: 148–153. 2013. doi:10.1007/s11419-013-0205-6.
- ↑ 5.0 5.1 "Craze manufacturer disputes NSF's discovery of drug tainting". Nutraingredients. October 17, 2013. http://www.nutraingredients-usa.com/Regulation/Craze-manufacturer-disputes-NSF-s-discovery-of-drug-tainting.
- ↑ "Identification of N-ethyl-α-ethylphenethylamine in crystalline powder seized for suspected drug trafficking: A research chemical or a new designer drug?". Forensic Toxicology 31: 54–58. January 2013. doi:10.1007/s11419-012-0158-1.
- ↑ "Popular sports supplements contain meth-like compound". USA Today. October 25, 2013. https://www.usatoday.com/story/news/nation/2013/10/14/tests-of-supplements-craze-and-detonate-find-methamphetamine-like-compound/2968041/.
- ↑ "A methamphetamine analog (N,α-diethyl-phenylethylamine) identified in a mainstream dietary supplement". Drug Testing and Analysis 6 (7-8): 805–7. 2014. doi:10.1002/dta.1578. PMID 24124092.
- ↑ Warning issued over CRAZE sports supplement. New Zealand Herald, 13 November 2013
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