Chemistry:Prolintane
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Prolintane is a central nervous system (CNS) stimulant[1] and norepinephrine–dopamine reuptake inhibitor (NDRI) of the phenylalkylpyrrolidine family developed in the 1950s.[2] Being an amphetamine derivative, it is closely related in chemical structure to other drugs such as pyrovalerone, MDPV, and propylhexedrine, and has a similar mechanism of action.[3] Many cases of prolintane abuse have been reported.[4]
Under the brand name Katovit, prolintane was commercialized by the Spanish pharmaceutical company FHER until 2001. It was most often used by students and workers as a stimulant to provide energy and increase alertness and concentration.[5] Prolintane and substituted prolintane analogs (fluoro and methyl) show DAT and NET inhibition in the low nanomolar range, which is consistent with NDRI psychostimulants such a methylphenidate.[5] In addition 4-substituted analogs have SERT inhibition which correlates with amphetamine SAR such as fenfluramine.[5]
See also
- α-PVP (β-ketone-prolintane, prolintanone)
- Methylenedioxypyrovalerone (MDPV)
- Pyrovalerone (Centroton, Thymergix)
- Phenylpropylaminopentane (PPAP)
References
- ↑ "A new stimulant, prolintane hydrochloride, compared with dextroamphetamine in fatigued volunteers". The Journal of Clinical Pharmacology and the Journal of New Drugs 10 (2): 103–109. March–April 1970. doi:10.1177/009127007001000205. PMID 4392006.
- ↑ "New tertiary amines and their salts and process for their preparation" GB patent 807835, published 1959-01-21, assigned to Dr Karl Thomae GmbHand Boehringer Ingelheim Pharma GmbH and Co KG
- ↑ "Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline". British Journal of Clinical Pharmacology 10 (5): 465–472. November 1980. doi:10.1111/j.1365-2125.1980.tb01790.x. PMID 7437258.
- ↑ "Domestic abuse of the European rave drug prolintane". Journal of Analytical Toxicology 31 (7): 415–418. September 2007. doi:10.1093/jat/31.7.415. PMID 17725890.
- ↑ 5.0 5.1 5.2 "Prolintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences". The Journal of Biological Chemistry 301 (12). December 2025. doi:10.1016/j.jbc.2025.110903. PMID 41197716.
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