Chemistry:Prolintane

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Prolintane is a central nervous system (CNS) stimulant[1] and norepinephrine–dopamine reuptake inhibitor (NDRI) of the phenylalkylpyrrolidine family developed in the 1950s.[2] Being an amphetamine derivative, it is closely related in chemical structure to other drugs such as pyrovalerone, MDPV, and propylhexedrine, and has a similar mechanism of action.[3] Many cases of prolintane abuse have been reported.[4]

Under the brand name Katovit, prolintane was commercialized by the Spanish pharmaceutical company FHER until 2001. It was most often used by students and workers as a stimulant to provide energy and increase alertness and concentration.[5] Prolintane and substituted prolintane analogs (fluoro and methyl) show DAT and NET inhibition in the low nano molecular range, which is consistent with NDRI psychostimulants such a methylphenidate.[6] In addition 4-substituted analogs have SERT inhibition which correlates with amphetamine SAR such as fenfluramine.[7]

See also

References

  1. ↑ "A new stimulant, prolintane hydrochloride, compared with dextroamphetamine in fatigued volunteers". The Journal of Clinical Pharmacology and the Journal of New Drugs 10 (2): 103–9. March–April 1970. doi:10.1177/009127007001000205. PMID 4392006. 
  2. ↑ GB Patent 807835
  3. ↑ "Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline". British Journal of Clinical Pharmacology 10 (5): 465–72. November 1980. doi:10.1111/j.1365-2125.1980.tb01790.x. PMID 7437258. 
  4. ↑ "Domestic abuse of the European rave drug prolintane". Journal of Analytical Toxicology 31 (7): 415–8. September 2007. doi:10.1093/jat/31.7.415. PMID 17725890. 
  5. ↑ https://www.jbc.org/article/S0021-9258(25)02755-3/fulltext
  6. ↑ https://www.jbc.org/article/S0021-9258(25)02755-3/fulltext
  7. ↑ https://www.jbc.org/article/S0021-9258(25)02755-3/fulltext



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