Chemistry:Cericlamine

Cericlamine
Clinical data
Routes of; administration	Oral
ATC code	None;
Pharmacokinetic data
Elimination half-life	8 hours
Identifiers
	IUPAC name 3-(3,4-Dichlorophenyl)-2-(dimethylamino)-2-methylpropan-1-ol;
CAS Number	112922-55-1;
PubChem CID	131074;
ChemSpider	115890;
UNII	VES82D23IB;
Chemical and physical data
Formula	C12H17Cl2NO
Molar mass	262.17 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(CC1=CC(=C(C=C1)Cl)Cl)(CO)N(C)C;
	InChI InChI=1S/C12H17Cl2NO/c1-12(8-16,15(2)3)7-9-4-5-10(13)11(14)6-9/h4-6,16H,7-8H2,1-3H3; Key:FWYRGHMKHZXXQX-UHFFFAOYSA-N;

Short description: Chemical compound

Cericlamine (INN; developmental code JO-1017) is a potent and moderately selective serotonin reuptake inhibitor (SSRI) of the amphetamine family (specifically, a derivative of phentermine, and closely related to chlorphentermine, a highly selective serotonin releasing agent) that was investigated as an antidepressant for the treatment of depression, anxiety disorders, and anorexia nervosa by Jouveinal but did not complete development and was never marketed.^[1]^[2]^[3]^[4] It reached phase III clinical trials in 1996 before development was discontinued in 1999.^[5]

According to Czech scientists, cericlamine is claimed to be part of a highly advanced “fifth generation” of antidepressants as was venlafaxine.^[6]

The daily dosage was reported to be 300mg.^[1]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 "A Multicentre Double-Blind, Placebo-Controlled Dose-Finding Study with Cericlamine in Major Depression". Clinical Neuropharmacology 15: 176B. 1992. doi:10.1097/00002826-199202001-00339. ISSN 0362-5664.
↑ "Investigational drugs for eating disorders". Expert Opinion on Investigational Drugs 12 (3): 491–9. March 2003. doi:10.1517/13543784.12.3.491. PMID 12605570.
↑ Stereoselective Biocatalysis. CRC Press. 3 January 2000. pp. 48–. ISBN 978-0-8247-8282-5. https://books.google.com/books?id=QwgCzKDfNAoC&pg=PA48.
↑ Neurochemistry in Clinical Application. Springer Science & Business Media. 6 December 2012. pp. 81–. ISBN 978-1-4615-1857-0. https://books.google.com/books?id=d2DlBwAAQBAJ&pg=PA81.
↑ "Cericlamine". AdisInsight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800001340.
↑ Svestka, J. (1994). "Antidepressives of the 3rd, 4th and 5th generation". Ceskoslovenska Psychiatrie 90 (1): 3–19. PMID 8174184.

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Original source: https://en.wikipedia.org/wiki/Cericlamine. Read more

[DarcourtTessera1992-1] 1.0 ^1.1 ^1.2 ^1.3 "A Multicentre Double-Blind, Placebo-Controlled Dose-Finding Study with Cericlamine in Major Depression". Clinical Neuropharmacology 15: 176B. 1992. doi:10.1097/00002826-199202001-00339. ISSN 0362-5664.

[CrowBrown2003-2] "Investigational drugs for eating disorders". Expert Opinion on Investigational Drugs 12 (3): 491–9. March 2003. doi:10.1517/13543784.12.3.491. PMID 12605570.

[Patel2000-3] Stereoselective Biocatalysis. CRC Press. 3 January 2000. pp. 48–. ISBN 978-0-8247-8282-5. https://books.google.com/books?id=QwgCzKDfNAoC&pg=PA48.

[TangTang2012-4] Neurochemistry in Clinical Application. Springer Science & Business Media. 6 December 2012. pp. 81–. ISBN 978-1-4615-1857-0. https://books.google.com/books?id=d2DlBwAAQBAJ&pg=PA81.

[AdisInsight-5] "Cericlamine". AdisInsight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800001340.

[6] Svestka, J. (1994). "Antidepressives of the 3rd, 4th and 5th generation". Ceskoslovenska Psychiatrie 90 (1): 3–19. PMID 8174184.

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v t e Phenethylamines
Phenethylamines	Psychedelics: 25B-NBOMe 25C-NBOMe 25D-NBOMe 25I-NBOMe 25N-NBOMe 2C-B 2C-B-AN 2C-Bn 2C-Bu 2C-C 2C-CN 2C-CP 2C-D 2C-E 2C-EF 2C-F 2C-G 2C-G-1 2C-G-2 2C-G-3 2C-G-4 2C-G-5 2C-G-6 2C-G-N 2C-H 2C-I 2C-iP 2C-N 2C-NH2 2C-O 2C-O-4 2C-P 2C-Ph 2C-SE 2C-T 2C-T-2 2C-T-3 2C-T-4 2C-T-5 2C-T-6 2C-T-7 2C-T-8 2C-T-9 2C-T-10 2C-T-11 2C-T-12 2C-T-13 2C-T-14 2C-T-15 2C-T-16 2C-T-17 2C-T-18 2C-T-19 2C-T-20 2C-T-21 2C-T-22 2C-T-22.5 2C-T-23 2C-T-24 2C-T-25 2C-T-27 2C-T-28 2C-T-30 2C-T-31 2C-T-32 2C-T-33 2C-TFE 2C-TFM 2C-YN 2C-V Allylescaline DESOXY Escaline Isoproscaline Jimscaline Macromerine MEPEA Mescaline Metaescaline Methallylescaline Proscaline Psi-2C-T-4 TCB-2 Stimulants: Phenylethanolamine Hordenine Phenethylamine α-Methylphenethylamine (amphetamine) β-Methylphenethylamine m-Methylphenethylamine N-Methylphenethylamine o-Methylphenethylamine p-Methylphenethylamine Methylphenidate Entactogens: Lophophine MDPEA MDMPEA Others: BOH DMPEA
Amphetamines	Psychedelics: 3C-BZ 3C-E 3C-P Aleph Beatrice Bromo-DragonFLY D-Deprenyl DMA DMCPA DMMDA DOB DOC DOEF DOET DOI DOM DON DOPR DOTFM Ganesha MMDA MMDA-2 Psi-DOM TMA TeMA Stimulants: 2-FA 2-FMA 3-FA 3-FMA Acridorex Alfetamine Amfecloral Amfepentorex Amphetamine (Dextroamphetamine, Levoamphetamine) Amphetaminil Benfluorex Benzphetamine Cathine Clobenzorex Dimethylamphetamine Ephedrine Etilamfetamine Fencamfamin Fencamine Fenethylline Fenfluramine (Dexfenfluramine, Levofenfluramine) Fenproporex Flucetorex Fludorex Formetorex Furfenorex Gepefrine 4-Hydroxyamphetamine Iofetamine Isopropylamphetamine Lefetamine Lisdexamfetamine Mefenorex Metaraminol Methamphetamine (Dextromethamphetamine, Levomethamphetamine) Methoxyphenamine MMA Morforex Norfenfluramine L -Norpseudoephedrine N,alpha-Diethylphenylethylamine Oxifentorex Oxilofrine Ortetamine PBA PCA Phenpromethamine PFA PFMA PIA PMA PMEA PMMA Phenylpropanolamine Pholedrine Prenylamine Propylamphetamine Pseudoephedrine Sibutramine Tiflorex Tranylcypromine Xylopropamine Zylofuramine Entactogens: 4-FA 4-FMA 4-MA 4-MMA 4-MTA 5-APB 5-APDB 5-EAPB 5-IT 5-MAPB 5-MAPDB 6-APB 6-APDB 6-Chloro-MDMA 6-EAPB 6-IT 6-MAPB 6-MAPDB EDA IAP 2,3-MDA 3,4-MDA (tenamfetamine) MDEA MDHMA MDMA (midomafetamine) MDOH Methamnetamine MMDMA Naphthylaminopropane TAP Others: 3,4-DCA Amiflamine DiFMDA Selegiline (also D -Deprenyl)
Phentermines	Stimulants: Chlorphentermine Cloforex Clortermine Etolorex Mephentermine Pentorex Phentermine Entactogens: MDPH MDMPH Others: Cericlamine
Cathinones	Stimulants: 3-FMC 4-MC 4-BMC 4-CMC 4-EMC 4-FMC 4-MEC 4-MeMABP 4-MPD Amfepramone Benzedrone Brephedrone Buphedrone Bupropion Cathinone Dimethylcathinone Ethcathinone Eutylone Hydroxybupropion Methcathinone Methedrone NEB N-Ethylhexedrone N-Ethylpentedrone Pentedrone Pentylone Radafaxine Entactogens: 3,4-DMMC 3-MMC Butylone Ethylone Methylone Methylenedioxycathinone Mephedrone
Phenylisobutylamines	Entactogens: 4-CAB 4-MAB Ariadne BDB Butylone EBDB Eutylone MBDB Stimulants: Phenylisobutylamine
Phenylalkylpyrrolidines	Stimulants: α-PBP α-PHP α-PPP α-PVP MDPBP MDPPP MDPV 4-MePBP 4-MePHP 4-MePPP MOPPP MOPVP MPBP MPHP MPPP Naphyrone PEP Prolintane Pyrovalerone
Catecholamines (and close relatives)	6-FNE 6-OHDA a-Me-DA a-Me-TRA Adrenochrome Ciladopa D -DOPA (Dextrodopa) Dimetofrine Dopamine Epinephrine Epinine Etilefrine Ethylnorepinephrine Fenclonine Ibopamine Isoprenaline Isoetarine L -DOPA (Levodopa) L -DOPS (Droxidopa) L -Phenylalanine L -Tyrosine m-Tyramine Metanephrine Metaraminol Metaterol Metirosine Methyldopa N,N-Dimethyldopamine Nordefrin (Levonordefrin) Norepinephrine Norfenefrine (m-Octopamine) Normetanephrine Orciprenaline p-Octopamine p-Tyramine Phenylephrine Synephrine
Miscellaneous	AL-LAD Amidephrine Arbutamine Cafedrine Denopamine Desvenlafaxine Diphenidine Dizocilpine Dobutamine Dopexamine Ephenidine Etafedrine ETH-LAD Famprofazone Fluorolintane Hexapradol IP-LAD Lysergic acid amide Lysergic acid 2-butyl amide Lysergic acid 2,4-dimethylazetidide Lysergic acid diethylamide Methoxamine Methoxphenidine MT-45 PARGY-LAD Phenibut PRO-LAD Pronethalol Salbutamol (Levosalbutamol) Solriamfetol Theodrenaline Thiamphenicol UWA-101

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Clinical data

Routes of administration	Oral^[1]
ATC code	None
Pharmacokinetic data
Elimination half-life	8 hours^[1]
Identifiers
IUPAC name 3-(3,4-Dichlorophenyl)-2-(dimethylamino)-2-methylpropan-1-ol
CAS Number	112922-55-1
PubChem CID	131074
ChemSpider	115890
UNII	VES82D23IB
Chemical and physical data
Formula	C₁₂H₁₇Cl₂NO
Molar mass	262.17 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(CC1=CC(=C(C=C1)Cl)Cl)(CO)N(C)C
InChI InChI=1S/C12H17Cl2NO/c1-12(8-16,15(2)3)7-9-4-5-10(13)11(14)6-9/h4-6,16H,7-8H2,1-3H3 Key:FWYRGHMKHZXXQX-UHFFFAOYSA-N

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Chemistry:Cericlamine

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