Chemistry:Pentedrone
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| Formula | C12H17NO |
| Molar mass | 191.274 g·mol−1 |
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Pentedrone (also known as α-methylaminovalerophenone) is a stimulant of the cathinone class that has been sold as a designer drug and has been found since 2010 as an ingredient in a number of "bath salt" mixes sold as legal highs.[2][3][4][5][6][7][8]
Pharmacology
Pentedrone acts as a norepinephrine-dopamine reuptake inhibitor without causing their release, the same mechanism of action as methylphenidate.[9][10]
Side effects
Pentedrone has been linked to at least one death where it was combined with α-PVP and caused heart failure.[11]
Detection
A forensic standard of pentedrone is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[12]
Legal status
On January 28, 2014, the DEA listed it, along with nine other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.[13]
Pentedrone is an Anlage II controlled drug in Germany.
As of October 2015 Pentedrone is a controlled substance in China.[14]
Pentedrone is banned in the Czech Republic.[15]
See also
References
- ↑ "Substance Details Pentedrone". https://www.unodc.org/LSS/Substance/Details/1e25cb1f-9760-4cd8-9032-fcf11461e4e7.
- ↑ "EMCDDA Annual Report 2010". http://www.emcdda.europa.eu/attachements.cfm/att_132857_EN_EMCDDA-Europol%20Annual%20Report%202010A.pdf.
- ↑ Research on Head Shop drugs in Dublin: Part 2
- ↑ An overview of new psychoactive substances and the outlets supplying them
- ↑ "Mass, NMR and IR spectroscopic characterization of pentedrone and pentylone and identification of their isocathinone by-products". Forensic Science International 217 (1–3): 157–67. April 2012. doi:10.1016/j.forsciint.2011.10.045. PMID 22115724. http://www.fsijournal.org/article/S0379-0738%2811%2900533-0/abstract.
- ↑ "Chemical analysis of two new designer drugs: buphedrone and pentedrone". Drug Testing and Analysis 4 (1): 17–23. January 2012. doi:10.1002/dta.385. PMID 22113925.
- ↑ "Analysis of the first- and second-generation Raving Dragon Novelty Bath Salts containing methylone and pentedrone". Journal of Forensic Sciences 60 Suppl 1 (11): S234–40. January 2015. doi:10.1111/1556-4029.12629. PMID 25470207.
- ↑ "Analytical profiles of "legal highs" containing cathinones available in the area of Lisbon, Portugal". Forensic Science International 244: 102–10. November 2014. doi:10.1016/j.forsciint.2014.08.010. PMID 25240621. http://www.fsijournal.org/article/S0379-0738%2814%2900324-7/abstract.
- ↑ "Monoamine transporter and receptor interaction profiles of a new series of designer cathinones". Neuropharmacology 79: 152–60. April 2014. doi:10.1016/j.neuropharm.2013.11.008. PMID 24275046. http://onlinelibrary.wiley.com/doi/10.1002/dta.385/abstract.
- ↑ "The new stimulant designer compound pentedrone exhibits rewarding properties and affects dopaminergic activity". Addiction Biology 22 (1): 117–128. January 2017. doi:10.1111/adb.12299. PMID 26290055.
- ↑ "A Fatal Case of Pentedrone and α-Pyrrolidinovalerophenone Poisoning". Journal of Analytical Toxicology 39 (4): 324–9. May 2015. doi:10.1093/jat/bkv011. PMID 25737339.
- ↑ "Pentedrone". Southern Association of Forensic Scientists. http://forendex.southernforensic.org/index.php/detail/index/1164.
- ↑ "Temporary Placement of 10 Synthetic Cathinones into Schedule I". 28 January 2014. http://www.deadiversion.usdoj.gov/fed_regs/rules/2014/fr0128.htm.
- ↑ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. http://www.sfda.gov.cn/WS01/CL0056/130753.html.
- ↑ "Látky, o které byl doplněn seznam č. 4 psychotropních látek (příloha č. 4 k nařízení vlády č. 463/2013 Sb.)" (in Czech). Ministerstvo zdravotnictví. http://www.mzcr.cz/Admin/_upload/files/3/Nov%C3%A9%20PL.pdf.
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