Chemistry:Phenpromethamine
From HandWiki
Short description: Sympathomimetic nasal decongestant (Phenethylamine group)
 | |
| Clinical data | |
|---|---|
| Trade names | Vonedrine |
| Other names | N,β-Dimethylphenethylamine; N,β-Dimethylbenzeneethanamine; Phenylpropylmethylamine |
| ATC code |
|
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C10H15N |
| Molar mass | 149.237 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
Phenpromethamine (former brand name Vonedrine), also known as N,β-dimethylphenethylamine, is a sympathomimetic nasal decongestant of the phenethylamine group.[1][2][3][4] It was previously marketed as a nasal inhaler from 1943 through 1960 but is no longer available.[4][3][5] The medication is a stimulant and is banned by the World Anti-Doping Agency.[6][3] It has been detected in dietary supplements starting in the 2010s.[5][4]
See also
References
- ↑ "The Condensation of Unsaturated Amines with Aromatic Compounds. The Preparation of β-Substituted Phenethylamines". Journal of the American Chemical Society 65 (4): 674–677. 1943. doi:10.1021/ja01244a049. ISSN 0002-7863.
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 971–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA971.
- ↑ 3.0 3.1 3.2 "Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA)". British Journal of Pharmacology 154 (3): 606–22. June 2008. doi:10.1038/bjp.2008.124. PMID 18500382.
- ↑ 4.0 4.1 4.2 "Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine". Clinical Toxicology 59 (11): 975–981. March 2021. doi:10.1080/15563650.2021.1894333. PMID 33755516.
- ↑ 5.0 5.1 "A novel method to distinguish β-methylphenylethylamines from isomeric α-methylphenylethylamines by liquid chromatography coupled to electrospray ionization mass spectrometry". Forensic Toxicology 38 (2): 465–474. 2019. doi:10.1007/s11419-019-00511-z. ISSN 1860-8965.
- ↑ "The 2006 WADA Prohibited List: Summary of Revisions". 2006 Canadian Centre for Ethics in Sport Advisory Notice. http://www.cces.ca/pdfs/CCES-ADV-2006ListUpdate-E.pdf.
 |  |
