The α-methyl (i.e., amphetaminederivative is 1-(α-methylphenethyl)pyrrolidine (MPEP), the β-keto derivative is phenacylpyrrolidine, and the combined α-methyl and β-keto (i.e., cathinone) derivative is α-pyrrolidinopropiophenone (α-PPP).[1]Prolintane is the α-propyl derivative of PEP.[1]
All of these compounds differ from PEP in that the alpha carbon is extended and a ketone is attached to the beta carbon (with the exception of prolintane), among other modifications.[1]
A cyclized phenethylamine and 2-aminoindane derivative is Pyr-AI ((2-indanyl)pyrrolidine).[2] It is the analogue of 2-aminoindane (2-AI) in which the amine has been replaced with a pyrrolidine group.[2] The drug has been described as having strong and long-lasting amphetamine-like effects in rodents.[2][3]
↑ 2.02.12.2Brandt, Simon D.; Braithwaite, Robin A.; Evans-Brown, Michael; Kicman, Andrew T. (2013). "Aminoindane Analogues". Novel Psychoactive Substances. Elsevier. p. 261–283. doi:10.1016/b978-0-12-415816-0.00011-0. ISBN978-0-12-415816-0. https://linkinghub.elsevier.com/retrieve/pii/B9780124158160000110. Retrieved 2 November 2025. "A ‘strong amphetamine-type activity’ has been reported for the pyrrolidine derivative of 2-AI (26, Fig. 11.10) [41] and ‘a long duration’ of activity was observed at the 10mg/kg dose in mice. Details about the procedure were not provided but neuropharmacological screenings were based on observational methods [48]. A piperidine derivative (27, PIP-AI), on the other hand, showed analgesic properties comparable to meperidine [41]."
