Chemistry:Pholedrine
Pholedrine, also known as 4-hydroxy-N-methylamphetamine and sold under the brand names Paredrinol, Pulsotyl, and Veritol among others, is a sympathomimetic drug used in topical eye drops to dilate the pupil.[1][2][3] It can be used to diagnose Horner's syndrome.[3]
In 2004, it remained marketed only in Germany.[1]
Pharmacology
Pharmacodynamics
Pholedrine is described as a sympathomimetic, antihypotensive, and ephedrine-like agent.[4][1][5]
Chemistry
Pholedrine, also known as 4-hydroxy-N-methylamphetamine, is a substituted phenethylamine and amphetamine derivative.[4][1] It is structurally related to methamphetamine (N-methylamphetamine), norpholedrine (4-hydroxyamphetamine), oxilofrine (4,β-dihydroxy-N-methylamphetamine), and tyramine (4-hydroxyphenethylamine).
It is used pharmaceutically as the sulfate salt.[1][4]
The predicted log P of pholedrine ranges from 1.12 to 1.7.[2][6][7]
History
Pholedrine was synthesized by 1951.[4]
Society and culture
Names
Pholedrine is the generic name of the drug and its INN, BAN, and DCF, while foledrina is its DCIT.[4][1][5] The drug has been sold under brand names including Pholedrin Liquidum, Pholedrin-Longo-Isis, Presoitan, Veritain, and Veritol among others.[4][1]
Other drugs
Pholedrine (4-hydroxymethamphetamine) is also a major metabolite of methamphetamine.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Schweizerischer Apotheker-Verein (2004). Index Nominum: International Drug Directory. Medpharm Scientific Publishers. p. 969. ISBN 978-3-88763-101-7. https://books.google.com/books?id=EgeuA47Ocm4C&pg=PA969. Retrieved 30 August 2024.
- ↑ 2.0 2.1 "Pholedrine". National Library of Medicine. https://pubchem.ncbi.nlm.nih.gov/compound/4655.
- ↑ 3.0 3.1 "Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome". Journal of Neurology, Neurosurgery, and Psychiatry 58 (2): 215–217. February 1995. doi:10.1136/jnnp.58.2.215. PMID 7876854.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. 2014. p. 794. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA794. Retrieved 30 August 2024.
- ↑ 5.0 5.1 Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. 2012. p. 219. ISBN 978-94-011-4439-1. https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA219. Retrieved 30 August 2024.
- ↑ "Metabolite 4-hydroxymethamphetamine". https://go.drugbank.com/metabolites/DBMET00735.
- ↑ "Pholedrine". 21 July 2022. https://legacy.chemspider.com/Chemical-Structure.4494.html.
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