Chemistry:Aleph-4
Aleph-4, or ALEPH-4, also known as 4-isopropylthio-2,5-dimethoxyamphetamine, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families.[1] It is one of the Aleph series of compounds.[1] In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists Aleph-4's dose as 7 to 12 mg orally and its duration as 12 to 20 hours.[1] The effects of Aleph-4 have been reported to include closed-eye imagery, enhanced visual appreciation, emotional changes, and physical side effects and toxicity indications, among others.[1] One of the reports remarked that it was "one of the most profound and deep learning experiences" they had had.[1] However, Shulgin was unwilling to push the dose higher than 12 mg due to toxicity concerns.[1] The chemical synthesis of Aleph-4 has been described.[1] Aleph-4 was first described in the scientific literature by Shulgin, David E. Nichols, Peyton Jacob III, and other colleagues in 1978.[2] Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.[1] The drug was encountered as a novel designer drug in Japan in 2009.[3][4] It is a Schedule I controlled substance in the United States as an isomer of 2C-T-7.[5] The drug is also a controlled substance in Canada under phenethylamine blanket-ban language.[6]
See also
- DOx (psychedelics)
- Aleph (psychedelics)
- 2C-T-4
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml.https://erowid.org/library/books_online/pihkal/pihkal005.shtml
- ↑ "Mescaline Analogs: Substitutions at the 4-Position". QuaSAR: Quantitative Structure Activity Relationships Of Analgesics, Narcotic Antagonists, And Hallucinogens. National Institute on Drug Abuse Research Monograph Series. 22. National Institute on Drug Abuse. 1978. pp. 27–37. https://archives.nida.nih.gov/sites/default/files/monograph22.pdf#page=38.
- ↑ Suzuki, J., Moriyasu, T., Nagashima, M., Kanai, C., Shimizu, M., Hamano, T., & Nagayama, T. (2010). Analysis of uncontrolled drugs purchased in fiscal year 2009. Ann RepTokyo Metrop Inst Public Health [Japanese: Tōkyō-to Kenkō Anzen Kenkyū Sentā Kenkyū Nenpō], 61, 163–172. https://isomerdesign.com/bitnest/external/TokyoMetr.Inst.PH/61.163
- ↑ "2008年度買い上げ違法ドラッグ製品から検出された新規流通デザイナードラッグの同定" (in Japanese). Yakugaku Zasshi 130 (2): 263–70. February 2010. doi:10.1248/yakushi.130.263. PMID 20118651.
- ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf
- ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html.
External links
- Aleph-4 - Isomer Design
- Aleph-4 - PiHKAL - Erowid
- Aleph-4 - PiHKAL - Isomer Design
- Aleph-4 - The Shulgin Index
- Thioethers from PIHKAL, 2-C-T and ALEPH series - Fenderson5555 - YouTube
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