Chemistry:DOTMA
DOTMA, also known as 2,5-dimethoxy-3,4,6-trimethylamphetamine or as Julia, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families related to DOM.[1] It is the 3,6-dimethyl derivative of DOM and the 6-methyl derivative of Ganesha.[1] The drug is said to be the first and only known active phenethylamine psychedelic with a fully substituted phenyl ring.[1] However, the cyclized FLY phenethylamines such as 2C-B-FLY also have a fully substituted phenyl ring.[1]
DOTMA's dose is approximately 70 mg orally and its duration is 7 to 9 hours.[1] It is less potent than DOM, which is active at doses of 3 to 10 mg, and has a shorter duration than DOM, which lasts 14 to 20 hours.[1] Similarly, DOTMA is less potent and shorter-acting than Ganesha, which has a dose of 20 to 32 mg and a duration of 18 to 24 hours.[1]
DOTMA was described in the scientific literature by Daniel Trachsel in 2013.[1] The 6-methyl-DOM analogue of DOTMA and Ganesha, Juno, is relatively unknown but may be an active psychedelic as well.[1] DOTMA, or Julia, is closely related to Alexander Shulgin's "ten classic ladies".[2][3] It is a controlled substance in Canada due to phenethylamine blanket-ban language[4] but is not explicitly controlled in the United States.[5]
See also
- DOx (psychedelics)
- Juno (6-methyl-DOM)
- Ganesha (3-methyl-DOM)
- 2C-G (3-methyl-2C-D)
- PeMA
- TMePEA
- 2,6-Dimethylmescaline
- 2-Methylmescaline
- Xylopropamine (3,4-DMeA)
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. pp. 936–937. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ.
- ↑ Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml.
- ↑ "Triple Goddess of the Night". British Neuroscience Association Bulletin 63: 28–30. https://isomerdesign.com/bitnest/external/BNAB/63.30.
- ↑ "Controlled Drugs and Substances Act". 5 December 2025. https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html.
- ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf
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