Chemistry:Oxanamide

Oxanamide
Clinical data
ATC code	none;
Identifiers
	IUPAC name 2-ethyl-3-propyloxirane-2-carboxamide;
CAS Number	126-93-2;
PubChem CID	31365;
ChemSpider	29098;
UNII	050271194T;
Chemical and physical data
Formula	C8H15NO2
Molar mass	157.213 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCC1C(O1)(CC)C(=O)N;
	InChI InChI=1S/C8H15NO2/c1-3-5-6-8(4-2,11-6)7(9)10/h6H,3-5H2,1-2H3,(H2,9,10); Key:WBLPIVIXQOFTPQ-UHFFFAOYSA-N;
	(verify)

Short description: Chemical compound

Oxanamide (Quiactin) is an anxiolytic and muscle relaxant which can produce sedative and hypnotic effects in sufficiently high doses.^[1] An uncontrolled trial on patients treated in a clinical gynecology practice published in 1959 found that oxanamide was efficacious in the treatment of anxiety resulting from premenstrual syndrome, menopause, and various other causes, with minimal sedation or other side effects.^[2]

References

↑ "Effects of oxanamide on the central nervous system". Proceedings of the Society for Experimental Biology and Medicine 103: 101–3. January 1960. doi:10.3181/00379727-103-25425. PMID 14412594.
↑ "Oxanamide; adjunctive use of a new tranquilizer in gynecology". California Medicine 90 (4): 275–7. April 1959. PMID 13638840.

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Original source: https://en.wikipedia.org/wiki/Oxanamide. Read more

[1] "Effects of oxanamide on the central nervous system". Proceedings of the Society for Experimental Biology and Medicine 103: 101–3. January 1960. doi:10.3181/00379727-103-25425. PMID 14412594.

[2] "Oxanamide; adjunctive use of a new tranquilizer in gynecology". California Medicine 90 (4): 275–7. April 1959. PMID 13638840.

[1]

[2]

v t e Anxiolytics (N05B)
5-HT_1AR agonists	Buspirone Gepirone^† Tandospirone
GABA_AR PAMs	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Chlormezanone^‡ Ethanol (alcohol) Etifoxine Imepitoin; Herbs: Kava Skullcap Valerian
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIs (e.g., escitalopram) SNRIs (e.g., duloxetine) SARIs (e.g., trazodone) TCAs (e.g., clomipramine^#) TeCAs (e.g., mirtazapine) MAOIs (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cannabidiol Cycloserine Fabomotizole Hydroxyzine Kanna Lavender Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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Clinical data

ATC code	none
Identifiers
IUPAC name 2-ethyl-3-propyloxirane-2-carboxamide
CAS Number	126-93-2
PubChem CID	31365
ChemSpider	29098
UNII	050271194T
Chemical and physical data
Formula	C₈H₁₅NO₂
Molar mass	157.213 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCC1C(O1)(CC)C(=O)N
InChI InChI=1S/C8H15NO2/c1-3-5-6-8(4-2,11-6)7(9)10/h6H,3-5H2,1-2H3,(H2,9,10) Key:WBLPIVIXQOFTPQ-UHFFFAOYSA-N
(verify)

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