Chemistry:Plomestane
From HandWiki
Short description: Chemical compound
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| Other names | MDL-18962; Propargylestrenedione; PED; 10-(2-Propyn-1-yl)estr-4-ene-3,17-dione; 10-Propargylestr-4-ene-3,17-dione |
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| Formula | C21H26O2 |
| Molar mass | 310.437 g·mol−1 |
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Plomestane (INN, USAN; former developmental code name MDL-18962; also known as propargylestrenedione, PED) is a steroidal, irreversible aromatase inhibitor which was under development by Marion Merrell Dow/Hoechst Marion Russell (now Hoechst AG) as an antineoplastic agent for the treatment of breast cancer.[1][2][3][4][5] It was found to be effective in preclinical studies and was also found to produce few adverse effects in human clinical trials, significantly reducing estrogen levels with a single administration.[5] However, development of the drug for clinical use was halted due to "technical issues" and it was never marketed.[6]
In addition to its activity as an aromatase inhibitor, plomestane has weak androgenic properties.[5]
See also
References
- ↑ Dictionary of Pharmacological Agents. CRC Press. 1997. p. 1635. ISBN 978-0-412-46630-4. https://books.google.com/books?id=A0THacd46ZsC&pg=PA1635. Retrieved 19 May 2012.
- ↑ Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer. 1999. p. 227. ISBN 978-0-7514-0499-9. https://books.google.com/books?id=mqaOMOtk61IC&pg=PA227. Retrieved 20 May 2012.
- ↑ "The irreversible inhibition of aromatase (oestrogen synthetase) by steroidal compounds". Current Pharmaceutical Design (Bentham Science Publishers) 1: 23–50 (45). June 1995. doi:10.2174/1381612801666220524190226. https://books.google.com/books?id=qq8uPl5YYuoC&pg=PA45. Retrieved 20 May 2012.
- ↑ Exercise and Sport Nutrition. Exercise & Sport Nutrition. 2009. p. 350. ISBN 978-0-9742965-6-2. https://books.google.com/books?id=PW1ja6KxakC&pg=PA350. Retrieved 20 May 2012.
- ↑ 5.0 5.1 5.2 "Aromatase inhibitors as potential cancer chemopreventives". Cancer Epidemiology, Biomarkers & Prevention 7 (1): 65–78. January 1998. PMID 9456245. http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9456245.
- ↑ Medicinal Chemistry of Anticancer Drugs. Elsevier. 4 June 2008. p. 69. ISBN 978-0-444-52824-7. https://books.google.com/books?id=GjhXyqB5iLcC&pg=PA69. Retrieved 20 May 2012.
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