Chemistry:LGD-3303
From HandWiki
Short description: Chemical compound
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| Routes of administration | By mouth |
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| Formula | C16H14ClF3N2O |
| Molar mass | 342.75 g·mol−1 |
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LGD-3303 is a drug which acts as a selective androgen receptor modulator (SARM), with good oral bioavailability. It is a selective agonist for the androgen receptor, producing functional selectivity with effective dissociation of anabolic and androgenic effects, acting as a partial agonist for androgenic effects, but a full agonist for anabolic effects.[1] It has been investigated as a possible treatment for osteoporosis, and was shown in animal studies to enhance the effectiveness of a bisphosphonate drug.[2]
References
- ↑ "Pharmacokinetics and pharmacodynamics of LGD-3303 [9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-fquinolin-7(6H)-one], an orally available nonsteroidal-selective androgen receptor modulator"]. The Journal of Pharmacology and Experimental Therapeutics 328 (2): 663–70. February 2009. doi:10.1124/jpet.108.146811. PMID 19017848. http://jpet.aspetjournals.org/content/328/2/663.full.
- ↑ "Combination treatment with a selective androgen receptor modulator q(SARM) and a bisphosphonate has additive effects in osteopenic female rats". Journal of Bone and Mineral Research 24 (2): 231–40. February 2009. doi:10.1359/jbmr.081007. PMID 18847323.
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