Chemistry:Cyanonilutamide
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| Other names | RU-56279 |
| Drug class | Nonsteroidal antiandrogen |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C13H10F3N3O2 |
| Molar mass | 297.237 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Cyanonilutamide (developmental code name RU-56279) is a nonsteroidal antiandrogen which was never marketed.[1][2] Both RU-56187 and RU-58841 appear to be prodrugs of cyanonilutamide in vivo in animals.[2] It has relatively low affinity for the androgen receptor but nonetheless shows significant antiandrogenic activity in animals.[2]
See also
References
- ↑ "Selectively targeting prostate cancer with antiandrogen equipped histone deacetylase inhibitors". ACS Chem. Biol. 8 (11): 2550–60. November 2013. doi:10.1021/cb400542w. PMID 24004176.
- ↑ 2.0 2.1 2.2 "Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: relation of their systemic activity to the formation of a common metabolite". J. Steroid Biochem. Mol. Biol. 51 (1–2): 47–55. October 1994. doi:10.1016/0960-0760(94)90114-7. PMID 7947350.
 |  |
