Chemistry:Cl-4AS-1
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| Other names | N-(2-Chlorophenyl)-3-oxo-4-aza-4-methylandrost-1-en-17α-carboxamide |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| Chemical and physical data | |
| Formula | C26H33ClN2O2 |
| Molar mass | 441.01 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Cl-4AS-1 is a dual anabolic–androgenic steroid (AAS) and 5α-reductase inhibitor.[1][2] It is a potent and selective full agonist of the androgen receptor (IC50 = 12 nM) and inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively).[1][2] Structurally, Cl-4AS-1 is a 4-azasteroid.[1]
See also
References
- ↑ 1.0 1.1 1.2 "4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro]". J. Steroid Biochem. Mol. Biol. 60 (5–6): 303–9. 1997. doi:10.1016/s0960-0760(96)00199-9. PMID 9219921.
- ↑ 2.0 2.1 "Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands". J. Biol. Chem. 284 (52): 36367–76. 2009. doi:10.1074/jbc.M109.049734. PMID 19846549.
External links
 |  |
