Chemistry:Topterone
From HandWiki
Short description: Chemical compound
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| Other names | WIN-17665; Propyltestosterone; 17α-Propyltestosterone; 17α-Propylandrost-4-en-17β-ol-3-one |
| Routes of administration | Topical |
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| Formula | C22H34O2 |
| Molar mass | 330.512 g·mol−1 |
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Topterone (INN, USAN) (developmental code name WIN-17665), also known as 17α-propyltestosterone (or simply propyltestosterone) or as 17α-propylandrost-4-en-17β-ol-3-one, is a steroidal antiandrogen that was first reported in 1978 and was developed for topical administration but, due to poor effectiveness, was never marketed.[1][2][3][4][5][6]
See also
References
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 1–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=RA1-PA294.
- ↑ "Suppression of sebaceous gland development in laboratory animals by 17alpha-propyltestosterone". The Journal of Investigative Dermatology 71 (5): 320–323. November 1978. doi:10.1111/1523-1747.ep12529809. PMID 712108.
- ↑ "Chapter 18. Chemical Control of Androgen Action". Annual Reports in Medicinal Chemistry. 21. Academic Press. 1986. pp. 179–188 (183). doi:10.1016/S0065-7743(08)61128-8. ISBN 978-0-08-058365-5. https://books.google.com/books?id=qsFCGskRHZQC&pg=PA183.
- ↑ "Endocrine profile of topterone, a topical antiandrogen, in three species of laboratory animals". Methods and Findings in Experimental and Clinical Pharmacology 2 (2): 65–69. April 1980. PMID 7339330.
- ↑ "Mechanism of action of 17 alpha-propyltestosterone in inhibiting hamster flank organ development". The Journal of Investigative Dermatology 74 (1): 5–8. January 1980. doi:10.1111/1523-1747.ep12514560. PMID 7351494.
- ↑ "The Treatment of Acne". Pharmacology of the Skin II: Methods, Absorption, Metabolism and Toxicity, Drugs and Diseases. Springer Science & Business Media. 6 December 2012. pp. 490–. ISBN 978-3-642-74054-1. https://books.google.com/books?id=GvDxCAAAQBAJ&pg=PA490.
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