Chemistry:Atraric acid
From HandWiki
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| Names | |
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| Preferred IUPAC name
Methyl 2,4-dihydroxy-3,6-dimethylbenzoate | |
| Other names
Veramoss, Evernyl
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C10H12O4 | |
| Molar mass | 196.202 g·mol−1 |
| Melting point | 143–145 °C (289–293 °F; 416–418 K)[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
Atraric acid is a naturally occurring phenolic compound and ester with the IUPAC name methyl 2,4-dihydroxy-3,6-dimethylbenzoate and molecular formula C10H12O4.[2] It occurs in the root-bark of Pygeum africanum[3] and Evernia prunastri (Oakmoss). There is evidence to suggest that it has antiandrogenic activity in humans[3] and its use in treatment of benign prostate hyperplasia, prostate cancer, and spinal and bulbar muscular atrophy has been investigated.[2]
References
- ↑ Wang, Xiao-ning; Yu, Wen-tao; Lou, Hong-xiang (January 2005). "Antifungal Constituents from the Chinese MossHomalia trichomanoides". Chemistry & Biodiversity 2 (1): 139–145. doi:10.1002/cbdv.200490165. PMID 17191927.
- ↑ 2.0 2.1 ; Hans-Rainer Hoffmann & Rudolf Matusch"Isolation of Atraric Acid, Synthesis of Atraric Acid Derivatives, and Use of Atraric Acid and the Derivatives Thereof for the Treatment of Benign Prostatic Hyperplasia, Prostate Carcinoma and Spinobulbar Muscular Atrophy" US patent application 20090143466, published 2009-06-04, assigned to Aria Baniahmadand Hans-Rainer Hoffmann, Rudolf Matusch
- ↑ 3.0 3.1 Buss, Antony; Mark Butler (2010). Natural Product Chemistry for Drug Discovery. Royal Society of Chemistry. pp. 145, 146. ISBN 978-0-85404-193-0. https://books.google.com/books?id=1CvTBlGBicwC&q=%22atraric+acid%22&pg=PA145.
Other sources
- Fungal Associations – Google Books. p. 312.
- Watts' dictionary of chemistry - Henry Watts, Henry Forster Morley, Matthew Moncrieff Pattison Muir - Google Books. p. 361.
- Alternative and Complementary Therapies for Cancer: Integrative Approaches ... - Google Books. p. 489.
- STOJANOVIĆ, IGOR; NIKO S. RADULOVIĆ; TATJANA Lj MITROVIĆ; SLAVIŠA M. STAMENKOVIĆ; GORDANA S. STOJANOVIĆ (10 December 2010). Volatile Constituents of Parmeliaceai Lichens. Archived from the original on October 6, 2011. https://web.archive.org/web/20111006211320/http://www.doiserbia.nb.rs/img/doi/0352-5139/2011%20OnLine-First/0352-51391100087S.pdf.
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