Chemistry:Silandrone
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Short description: Chemical compound
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| Other names | Testosterone 17β-trimethylsilyl ether; Testosterone O-trimethylsilyl ether; 17β-Trimethylsilyltestosterone; O-Trimethylsilyltestosterone; 17β-(trimethylsiloxy)androst-4-en-3-one; SC-16148; NSC-95147 |
| Routes of administration | By mouth, intramuscular injection, subcutaneous injection |
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| Formula | C22H36O2Si |
| Molar mass | 360.613 g·mol−1 |
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Silandrone (INN, USAN) (developmental code name SC-16148), also known as testosterone 17β-trimethylsilyl ether or 17β-trimethylsilyltestosterone, as well as 17β-(trimethylsiloxy)androst-4-en-3-one, is a synthetic anabolic-androgenic steroid (AAS) and an androgen ether – specifically, the 17β-trimethylsilyl ether of testosterone – which was developed by the G. D. Searle & Company in the 1960s but was never marketed.[1] It has a very long duration of action when given via subcutaneous or intramuscular injection, as well as significantly greater potency than that of testosterone propionate.[2][3] In addition, silandrone, unlike testosterone and most esters of testosterone like testosterone propionate, is orally active.[4]
See also
References
- ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 642–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA642.
- ↑ "A singularly long-acting ether of testosterone". Proceedings of the Society for Experimental Biology and Medicine 123 (2): 303–4. November 1966. doi:10.3181/00379727-123-31472. PMID 5951069.
- ↑ "Prolonged reinstatement of sexual behavior in castrated male rats with an ether of testosterone, SC-16148". Hormones and Behavior 1 (2): 121–125. 1970. doi:10.1016/0018-506X(70)90004-8.
- ↑ Chinn, Leland J. (1969). The Chemistry and Biochemistry of Steroids. Geron-X. p. 97. ISBN 9780876720035. https://books.google.com/books?id=MZogAQAAIAAJ.
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