Chemistry:S-23 (drug)
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Short description: Investigational selective androgen receptor modulator
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| Formula | C18H13ClF4N2O3 |
| Molar mass | 416.76 g·mol−1 |
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S-23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.[1][2]
References
- ↑ "Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators". Journal of Medicinal Chemistry 47 (4): 993–8. February 2004. doi:10.1021/jm030336u. PMID 14761201.
- ↑ "Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception". Endocrinology 150 (1): 385–95. January 2009. doi:10.1210/en.2008-0674. PMID 18772237.
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