Chemistry:RU-58642
From HandWiki
Short description: Chemical compound
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| Drug class | Nonsteroidal antiandrogen |
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| Formula | C15H11F3N4O2 |
| Molar mass | 336.274 g·mol−1 |
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RU-58642 is a nonsteroidal antiandrogen (NSAA) derived from nilutamide with very high affinity and selectivity for the androgen receptor (AR), which made it among the most potent and efficacious antiandrogens known at the time of its discovery.[1] It was investigated for topical application for the treatment of androgenetic alopecia (male-pattern baldness), but development did not proceed past initial trial stages, and it is now only used for scientific research into the AR.[2][3]
See also
References
- ↑ "Pharmacological profile of RU 58642, a potent systemic antiandrogen for the treatment of androgen-dependent disorders". The Journal of Steroid Biochemistry and Molecular Biology 64 (1–2): 103–11. January 1998. doi:10.1016/S0960-0760(97)00151-9. PMID 9569015.
- ↑ "A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice". The Journal of Clinical Investigation 111 (9): 1319–27. May 2003. doi:10.1172/JCI17246. PMID 12727923.
- ↑ "Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor". The Journal of Clinical Investigation 116 (9): 2500–9. September 2006. doi:10.1172/JCI28809. PMID 16955145.
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