Chemistry:Rosterolone
From HandWiki
Short description: Chemical compound
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| Other names | SH-434; 17α-Propylmesterolone; 17β-Hydroxy-1α-methyl-17α-propyl-5α-androstan-3-one |
| Routes of administration | Topical |
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| Formula | C23H38O2 |
| Molar mass | 346.555 g·mol−1 |
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Rosterolone (INN) (developmental code name SH-434), also known as 17α-propylmesterolone or 1α-methyl-17α-propyl-5α-androstan-17β-ol-3-one, is a steroidal antiandrogen which was first described in 1984 and was developed for topical administration but was never marketed.[1][2] It has shown some efficacy in the treatment of acne, and lacks systemic effects with either topical or systemic administration.[3][1][2] Rosterolone is a derivative of mesterolone, which, in contrast, is an androgen and anabolic steroid.[citation needed]
See also
References
- ↑ 1.0 1.1 "17 alpha-Propylmesterolone (SH 434): an antiandrogenic sebosuppressive substance not influencing circulating testosterone concentrations. Experimental studies in Syrian hamsters". Naunyn-Schmiedeberg's Archives of Pharmacology 328 (2): 214–8. December 1984. doi:10.1007/BF00512076. PMID 6527707.
- ↑ 2.0 2.1 "Androgen receptor antagonists (antiandrogens): structure-activity relationships". Current Medicinal Chemistry 7 (2): 211–47. February 2000. doi:10.2174/0929867003375371. PMID 10637363.
- ↑ "Antiandrogens and Hair Growth: Basic Concepts and Experimental Research". Hair and Hair Diseases. Springer. 1990. pp. 791–826. doi:10.1007/978-3-642-74612-3_34. ISBN 978-3-642-74614-7.
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