Chemistry:Pyridoxiphen

From HandWiki

Pyridoxiphen, also known as amphetamine–pyridoxine condensation product or as pyridoxylamphetamine, is a drug of the substituted amphetamine family which was developed in the Soviet Union in the 1960s.[1][2][3][4][5][6] It is the condensation product of amphetamine (phenamine) and pyridoxine (vitamin B6).[2] It was developed for potential treatment of central nervous system conditions.[2] The drug has sympatholytic and hypotensive effects in animals.[7][1][6][8] It is highly ionic and may not be able to cross the blood–brain barrier.[7]

See also

  • Phenatine (N-nicotinoylamphetamine; amphetamine–niacin condensation product)
  • List of Russian drugs

References

  1. ↑ 1.0 1.1 Russian Drug Index. Public Health Service publication. U.S. Department of Health, Education, and Welfare, Public Health Service. 1967. p. 245. https://books.google.com/books?id=bOhsAAAAMAAJ&pg=PA245. Retrieved 4 October 2024. "Pyridoxiphen (Piridoksifen). 4-Pyridinemethanol, 3-hydroxy-2-methyl-5-((α-methylphenethyl)amino)methyl)-, dihydrochloride. C17H22N2O2.2HCl. [Structure image.] Product of condensation of phenamine and pyridoxine.. Arbuzov SI, Smirnova SM 1964" ; "Sympatholytic and hypotensive effects of pyridoxiphen". Farmakologiia i toksikologiia. 27: 420-423. 1964. PMID 14193108. 
  2. ↑ 2.0 2.1 2.2 (in it) International Socialist Miscellany. 1963. p. 131. https://books.google.com/books?id=NGcZAAAAMAAJ. Retrieved 4 October 2024. "Our chair has also produced certain derivatives of phenatin which likewise possess valuable qualities. For instance, there is pyridoxiphen, a product of condensation of phenamin and pyridoxine (Vitamin B3). This preparation is necessary in clinical practice for treating some of the diseases of the nervous system. We are persistently looking for even more active stimulators. This calls for a still deeper knowledge of the processes of metabolism in the nervous tissues, processes that lead to the exhaustion of these tissues, This will provide man with a means of conquering fatigue for long." 
  3. ↑ Pharmacological and Chemical Synonyms: A Collection of Names of Drugs, Pesticides and Other Compounds Drawn from the Medical Literature of the World. Excerpta Medica. 1983. pp. 30,419. ISBN 978-90-219-3061-9. https://books.google.com/books?id=8w-0AAAAIAAJ. Retrieved 4 October 2024. "PYRIDOXIPHEN (tr) (amphetamine-pyridoxine condensation product)" 
  4. ↑ "[On the action of pyridoxyphen on central nervous system]" (in Russian). Farmakologiia I Toksikologiia 29 (5): 521–522. 1966. PMID 5995060. 
  5. ↑ "[On the effect of pyridoxiphen on some functions of the nervous system]" (in Russian). Farmakologiia I Toksikologiia 31 (2): 152–156. 1968. PMID 5674665. 
  6. ↑ 6.0 6.1 Aerospace Technology Division, Library of Congress. "CBE Factors Monthly Survey No. 40, ATD Work Assignment No. 50 (ATD Report 69-77-50-10)". https://apps.dtic.mil/sti/tr/pdf/AD0687457.pdf. "Compound I does not display the pronounced hypotensive action characteristic of Pirodoksifen (i.e., pyridoxylamphetamine) and Fenatin (i.e., nicotinoylamphetamine) nor the central stimulating effect of Fenatin." 
  7. ↑ 7.0 7.1 Soviet Research in Pharmacology and Toxicology, 1963-1972. DHEW publication no. (NIH) 75-696. National Institutes of Health. 1974. pp. 22,77. https://books.google.com/books?id=3O3qzqQtGTUC&pg=PA22. Retrieved 4 October 2024. "C. Other Drug Effects (32) investigated the action of Arbuzov, Aleksandrova et al. pyridoxyphen, a new adrenolytic, on the central nervous system. Pyridoxyphen, a product of the condensation of phenamine and pyridoxine, exerted no central adrenolytic action. Because of the highly ionic nature of the molecule, the authors concluded that pyridoxyphen was incapable of overcoming the hemato-encephalic barrier." 
  8. ↑ "Simpatoliticheskoe i gipotenzivnoe de istvie piridoksifena" (in Russian). Farmakologiia I Toksikologiia 27: 420–423. 1964. PMID 14193108. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Pyridoxiphen&oldid=4037726"