Chemistry:Pheneturide
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| Formula | C11H14N2O2 |
| Molar mass | 206.245 g·mol−1 |
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| Chirality | Racemic mixture |
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Pheneturide (INN, BAN) (brand names Benuride, Deturid, Pheneturid, Septotence, Trinuride),[1] also known as phenylethylacetylurea (or ethylphenacemide), is an anticonvulsant of the ureide class.[2][3] Conceptually, it can be formed in the body as a metabolic degradation product from phenobarbital. It is considered to be obsolete[4] and is now seldom used.[5] It is marketed in Europe, including in Poland , Spain and the United Kingdom .[6] Pheneturide has a similar profile of anticonvulsant activity and toxicity relative to phenacemide.[7][8] As such, it is only used in cases of severe epilepsy when other, less-toxic drugs have failed.[8] Pheneturide inhibits the metabolism and thus increases the levels of other anticonvulsants, such as phenytoin.[5][6]
See also
References
- ↑ Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 998–. ISBN 978-3-7692-2114-5. https://books.google.com/books?id=HiSdvzs2pPAC&pg=PA998.
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 959–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA959.
- ↑ "1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide". Chirality 11 (7): 529–35. 1999. doi:10.1002/(SICI)1520-636X(1999)11:7<529::AID-CHIR3>3.0.CO;2-K. PMID 10423278.
- ↑ Antiepileptic Drugs. Lippincott Williams & Wilkins. 2002. pp. 210–. ISBN 978-0-7817-2321-3. https://books.google.com/books?id=HAOY0qG-vAYC&pg=PA210.
- ↑ 5.0 5.1 The Treatment of Medical Problems in the Elderly. Springer Science & Business Media. 6 December 2012. pp. 335–. ISBN 978-94-011-6223-4. https://books.google.com/books?id=VFIBCAAAQBAJ&pg=PT335.
- ↑ 6.0 6.1 Vida, Julius (19 July 2013). Anticonvulsants. Elsevier. pp. 4,42. ISBN 978-0-323-14395-0. https://books.google.com/books?id=u-qOecoMmqMC&pg=PA4.
- ↑ Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. Basel: Birkhäuser. 11 November 2013. pp. 217–. ISBN 978-3-0348-7161-7. https://books.google.com/books?id=2mT0BwAAQBAJ&pg=PA217. Retrieved 3 September 2016.
- ↑ 8.0 8.1 Lancaster, Richard (22 October 2013). Pharmacology in Clinical Practice. Elsevier. pp. 222–. ISBN 978-1-4831-9294-9. https://books.google.com/books?id=tQ8lBQAAQBAJ&pg=PA222.
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