Chemistry:2CT2-2-EtO

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2CT2-2-EtO, also known as 2-ethoxy-4-ethylthio-5-methoxyphenethylamine, is a psychedelic drug of the phenethylamine, 2C, and TWEETIO families related to 2C-T-2.[1][2][3] It is the derivative of 2C-T-2 in which the methoxy group at the 2 position has been replaced with an ethoxy group.[1][2][3]

According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT2-2-EtO has a "completely effective" dose of 50 mg orally, a typical dose of 10 mg intranasally but with considerable variation between individuals, and a duration of 5 to 6 hours or of 9 hours.[1][2][3] Its onset is said to be "very quick".[1] The effects of 2CT2-2EtO have been reported to include blurred vision, intense closed-eye visuals, generation of a pleasant and contemplative mood, restless sleep, and weird dreams.[1] Due to the large ~5-fold increase in potency when taken intranasally instead of orally, 2CT2-2EtO may undergo substantial first-pass metabolism with oral administration.[3]

The chemical synthesis of 2CT2-2-EtO has been described.[1]

2CT2-2-EtO was first described in the literature by Shulgin in PiHKAL in 1991.[1] It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin.[2][4][5][6][7] The drug is a controlled substance in Canada under phenethylamine blanket-ban language.[8]

See also

  • TWEETIO (psychedelics)

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. http://www.erowid.org/library/books_online/pihkal/pihkal.shtml.  "All three Tweetios of 2C-T-2 have been made and looked at through human eyes. The 2-EtO-homologue of 2C-T-2 is 2-ethoxy-4-ethylthio-5-methoxyphenethylamine, or 2CT2-2ETO. The benzaldehyde (2-ethoxy-4-ethylthio-5-methoxybenzaldehyde) had a melting point of 73-75 °C, the nitrostyrene intermediate a melting point of 122-123 °C, and the final hydrochloride a melting point of 202-204 °C. Fifty milligrams was a completely effective level. The effects were felt very quickly. Vision was blurred, and there were intense eyes-closed visuals and the generation of a pleasant, contemplative mood. Baseline was re-established in five or six hours, but sleep was restless, with weird dreams. Nasal administration showed considerable variation between individuals, but a typical dose was 10 milligrams."
  2. ↑ 2.0 2.1 2.2 2.3 "Basic Pharmacology and Effects". Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. 2003. pp. 67–137. ISBN 978-0-12-433951-4. https://bibliography.maps.org/resources/download/12634. 
  3. ↑ 3.0 3.1 3.2 3.3 (in de) Phenethylamine: von der Struktur zur Funktion. Nachtschatten-Science (1 ed.). Solothurn: Nachtschatten-Verlag. 2013. ISBN 978-3-03788-700-4. OCLC 858805226. https://books.google.com/books?id=-Us1kgEACAAJ. 
  4. ↑ "Erowid Darrell Lemaire Vault". https://erowid.org/culture/characters/lemaire_darrell/lemaire_darrell.shtml. 
  5. ↑ Morris H (7 December 2016). "The Lazy Lizard School of Hedonism". Hamilton's Pharmacopeia. Season 1. Episode 6. Vice Media. Viceland.
  6. ↑ "Notes About Psychoactive Compounds". Radiant Minds: Scientists Explore the Dimensions of Consciousness. Millay. 2010. pp. 201–207. ISBN 978-0-615-29633-3. https://erowid.org/culture/characters/lemaire_darrell/lemaire_darrell_article1.pdf. 
  7. ↑ Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez (2nd ed.). 1990. https://erowid.org/chemicals/2cd/2cd_smartpills1.pdf. 
  8. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 



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